Mouse Anti-EIF2B2 (AA 1-352) Recombinant Antibody (CBFYE-0181) (CBMAB-E0424-FY)

Name: Mouse Anti-EIF2B2 (AA 1-352) Recombinant Antibody (CBFYE-0181)
SKU: CBMAB-E0424-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYE-0181

Application

ELISA, IHC-P, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-352

More Infomation

Target

Full Name

Eukaryotic Translation Initiation Factor 2B Subunit Beta

Introduction

This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation.

Entrez Gene ID

8892

UniProt ID

P49770

Alternative Names

Eukaryotic Translation Initiation Factor 2B Subunit Beta; Eukaryotic Translation Initiation Factor 2B, Subunit 2 Beta, 39kDa; EIF-2B GDP-GTP Exchange Factor Subunit Beta; S20III15; S20I15; Eukaryotic Translation Initiation Factor 2B, Subunit 2 (Beta, 39kD)

Research Area

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

Biological Process

Central nervous system development Source: UniProtKB
Myelination Source: UniProtKB
Oligodendrocyte development Source: UniProtKB
Ovarian follicle development Source: UniProtKB
Regulation of catalytic activity Source: GOC
Regulation of translational initiation Source: UniProtKB
Response to glucose Source: UniProtKB
Response to heat Source: UniProtKB
Response to peptide hormone Source: UniProtKB
T cell receptor signaling pathway Source: UniProtKB
Translational initiation Source: UniProtKB

Cellular Location

Cytosol; Cytoplasm; Eukaryotic translation initiation factor 2B complex

Involvement in disease

Leukodystrophy with vanishing white matter (VWM):
A leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.

Filareto, I., Cinelli, G., Scalabrini, I., Caramaschi, E., Bergonzini, P., Spezia, E., ... & Iughetti, L. (2022). EIF2B2 gene mutation causing early onset vanishing white matter disease: a case report. Italian Journal of Pediatrics, 48(1), 1-9.

Wei, C., Qin, Q., Chen, F., Zhou, A., Wang, F., Zuo, X., ... & Jia, J. (2019). Adult-onset vanishing white matter disease with the EIF2B2 gene mutation presenting as menometrorrhagia. BMC neurology, 19(1), 1-10.

Moon, S. L., & Parker, R. (2018). EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response. Rna, 24(6), 841-852.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-EIF2B2 Recombinant Antibody (CBFYE-0181) (CAT#: V2LY-0425-LY1657)

Antibody Pairs

EIF2B2 Matched Antibody Pair (371) (CAT#: APMAB-371LY)

Related Products

Mouse Anti-EIF2B2 Recombinant Antibody (CBFYE-0181) (CAT#: V2LY-0425-LY1657)

EIF2B2 Matched Antibody Pair (371) (CAT#: APMAB-371LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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