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Mouse Anti-EIF2B5 Recombinant Antibody (CBFYE-0657) (CBMAB-E1070-FY)

This product is mouse antibody that recognizes EIF2B5. The antibody CBFYE-0657 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all EIF2B5 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYE-0657
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Eukaryotic Translation Initiation Factor 2B Subunit Epsilon
Introduction
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter.
Entrez Gene ID
Human8893
Mouse224045
Rat192234
UniProt ID
HumanQ13144
MouseQ8CHW4
RatQ64350
Alternative Names
Eukaryotic Translation Initiation Factor 2B Subunit Epsilon; Eukaryotic Translation Initiation Factor 2B, Subunit 5 Epsilon, 82kDa; EIF-2B GDP-GTP Exchange Factor Subunit Epsilon; Eukaryotic Translation Initiation Factor 2B, Subunit 5 (Epsilon, 82kD); Translation Initiation Factor EIF-2B Subunit Epsilon; EIF2Bepsilon
Research Area
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Biological Process
Aging Source: Ensembl
Astrocyte development Source: UniProtKB
Astrocyte differentiation Source: UniProtKB
Hippocampus development Source: Ensembl
Myelination Source: UniProtKB
Oligodendrocyte development Source: UniProtKB
Ovarian follicle development Source: UniProtKB
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of translational initiation Source: UniProtKB
Response to endoplasmic reticulum stress Source: UniProtKB
Response to glucose Source: UniProtKB
Response to heat Source: UniProtKB
Response to lithium ion Source: Ensembl
Response to peptide hormone Source: UniProtKB
T cell receptor signaling pathway Source: UniProtKB
Translational initiation Source: UniProtKB
Cellular Location
Cytosol; Nucleus; Cytoplasm; Eukaryotic translation initiation factor 2B complex
Involvement in disease
Leukodystrophy with vanishing white matter (VWM):
A leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.
PTM
Phosphorylated at Ser-544 by DYRK2; this is required for subsequent phosphorylation by GSK3B (By similarity). Phosphorylated on serine and threonine residues by GSK3B; phosphorylation inhibits its function.
Polyubiquitinated, probably by NEDD4.

He, S. L., Zhao, X., & Yi, S. J. (2022). CircAHNAK upregulates EIF2B5 expression to inhibit the progression of ovarian cancer by modulating the JAK2/STAT3 signaling pathway. Carcinogenesis.

Trevisan, L., Grazzini, M., Cianflone, A., Accogli, A., Finocchi, C., Capello, E., ... & Mandich, P. (2021). An eleven-year history of Vanishing White Matter Disease in an adult patient with no cognitive decline and EIF2B5 mutations. A case report. Neurocase, 27(6), 452-456.

Hou, L., Jiao, Y., Li, Y., Luo, Z., Zhang, X., Pan, G., ... & He, M. (2020). Low EIF2B5 expression predicts poor prognosis in ovarian cancer. Medicine, 99(5).

Keefe, M. D., Soderholm, H. E., Shih, H. Y., Stevenson, T. J., Glaittli, K. A., Bowles, D. M., ... & Bonkowsky, J. L. (2020). Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response. Elife, 9.

Terumitsu‐Tsujita, M., Kitaura, H., Miura, I., Kiyama, Y., Goto, F., Muraki, Y., ... & Igarashi, H. (2020). Glial pathology in a novel spontaneous mutant mouse of the Eif2b5 gene: a vanishing white matter disease model. Journal of Neurochemistry, 154(1), 25-40.

Rodríguez‐Palmero, A., Schlüter, A., Verdura, E., Ruiz, M., Martínez, J. J., Gourlaouen, I., ... & Pujol, A. (2020). A novel hypomorphic splice variant in EIF2B5 gene is associated with mild ovarioleukodystrophy. Annals of clinical and translational neurology, 7(9), 1574-1579.

Unterluggauer, J. J., Prochazka, K., Tomazic, P. V., Huber, H. J., Seeboeck, R., Fechter, K., ... & Haybaeck, J. (2018). Expression profile of translation initiation factor eIF2B5 in diffuse large B-cell lymphoma and its correlation to clinical outcome. Blood cancer journal, 8(9), 1-5.

Jiao, Y., Fu, Z., Li, Y., Meng, L., & Liu, Y. (2018). High EIF2B5 mRNA expression and its prognostic significance in liver cancer: a study based on the TCGA and GEO database. Cancer management and research, 10, 6003.

Bektaş, G., Yeşil, G., Özkan, M. U., Yıldız, E. P., Uzunhan, T. A., & Çalışkan, M. (2018). Vanishing white matter disease with a novel EIF2B5 mutation: A 10-year follow-up. Clinical neurology and neurosurgery, 171, 190-193.

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For research use only. Not intended for any clinical use.

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