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Rabbit Anti-EIF4G1 (Phospho-S1108) Recombinant Antibody (EG1078) (CBMAB-EN1274-LY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1078
Antibody Isotype
IgG
Application
WB, IF

Basic Information

Immunogen
Synthetic peptide corresponding to Human eIF4G1 (p Ser 1108).
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IF(ICC)1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BSA & Glycerol & PBS
Preservative
Sodium Azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Eukaryotic Translation Initiation Factor 4 Gamma 1
Introduction
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
Entrez Gene ID
1981
UniProt ID
Q04637
Alternative Names
Eukaryotic Translation Initiation Factor 4 Gamma 1; EIF-4-Gamma 1; EIF-4G1; EIF4GI; EIF4F; EIF4G; P220;
More Infomation

Zhao, Y., Li, C., Zhang, Y., & Li, Z. (2022). CircTMTC1 contributes to nasopharyngeal carcinoma progression through targeting miR-495-MET-eIF4G1 translational regulation axis. Cell death & disease, 13(3), 1-14.

Cruz, A., & Joseph, S. (2022). Interaction of the Influenza A Virus NS1 Protein with the 5′-m7G-mRNA· eIF4E· eIF4G1 Complex. Biochemistry, 61(14), 1485-1494.

Sehrawat, U., Haimov, O., Weiss, B., Tamarkin-Ben Harush, A., Ashkenazi, S., Plotnikov, A., ... & Dikstein, R. (2022). Inhibitors of eIF4G1–eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation. Proceedings of the National Academy of Sciences, 119(30), e2120339119.

Tseng, Y. T., Sung, Y. C., Liu, C. Y., & Lo, K. Y. (2022). Translation initiation factor eIF4G1 modulates the assembly of PET region in yeast ribosome biogenesis. Journal of Cell Science.

Saini, P., Rudakou, U., Yu, E., Ruskey, J. A., Asayesh, F., Laurent, S. B., ... & Gan-Or, Z. (2021). Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease. Neurobiology of Aging, 100, 119-e7.

Del Valle, L., Dai, L., Lin, H. Y., Lin, Z., Chen, J., Post, S. R., & Qin, Z. (2021). Role of EIF4G1 network in non‐small cell lung cancers (NSCLC) cell survival and disease progression. Journal of cellular and molecular medicine, 25(6), 2795-2805.

Trainor, B. M., Ghosh, A., Pestov, D. G., Hellen, C. U., & Shcherbik, N. (2021). A translation enhancer element from black beetle virus engages yeast eIF4G1 to drive cap-independent translation initiation. Scientific reports, 11(1), 1-18.

Jaiswal, P. K., Koul, S., Palanisamy, N., & Koul, H. K. (2019). Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1): a target for cancer therapeutic intervention?. Cancer cell international, 19(1), 1-14.

Haimov, O., Sehrawat, U., Tamarkin-Ben Harush, A., Bahat, A., Uzonyi, A., Will, A., ... & Dikstein, R. (2018). Dynamic interaction of eukaryotic initiation factor 4G1 (eIF4G1) with eIF4E and eIF1 underlies scanning-dependent and-independent translation. Molecular and cellular biology, 38(18), e00139-18.

Jaiswal, P. K., Koul, S., Shanmugam, P. S., & Koul, H. K. (2018). Eukaryotic Translation Initiation Factor 4 Gamma 1 (eIF4G1) is upregulated during Prostate cancer progression and modulates cell growth and metastasis. Scientific reports, 8(1), 1-12.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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