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Mouse Anti-ELF5 Recombinant Antibody (3D10) (CBMAB-A2573-LY)

The product is antibody recognizes ELF5. The antibody 3D10 immunoassay techniques such as: WB, ELISA.
See all ELF5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3D10
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
ELF5 (NP_938195.1, 166 a.a. ~ 263 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
E74 Like ETS Transcription Factor 5
Introduction
The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
Entrez Gene ID
2001
UniProt ID
Q9UKW6
Alternative Names
ESE2
Research Area
Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation.

Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters.
Biological Process
Cell differentiation Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Pietzner, M., Chua, R. L., Wheeler, E., Jechow, K., Willett, J. D., Radbruch, H., ... & Langenberg, C. (2022). ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19. Nature communications, 13(1), 1-15.

Pietzner, M., Chua, R. L., Wheeler, E., Jechow, K., Radbruch, H., Trump, S., ... & Langenberg, C. (2022). ELF5 is a respiratory epithelial cell-specific risk gene for severe COVID-19. medRxiv.

Miyano, M., Sayaman, R. W., Shalabi, S. F., Senapati, P., Lopez, J. C., Angarola, B. L., ... & LaBarge, M. A. (2021). Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation. Cancer Prevention Research, 14(8), 779-794.

Huang, Y., Chen, L., Feng, Z., Chen, W., Yan, S., Yang, R., ... & Ke, X. (2021). EPC-derived exosomal miR-1246 and miR-1290 regulate phenotypic changes of fibroblasts to endothelial cells to exert protective effects on myocardial infarction by targeting ELF5 and SP1. Frontiers in cell and developmental biology, 9, 647763.

Qu, X., Li, Q., Tu, S., Yang, X., & Wen, W. (2021). ELF5 inhibits the proliferation and invasion of breast cancer cells by regulating CD24. Molecular Biology Reports, 48(6), 5023-5032.

Singh, S., Kumar, S., Srivastava, R. K., Nandi, A., Thacker, G., Murali, H., ... & Chakrabarti, R. (2020). Loss of ELF5–FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling. Nature cell biology, 22(5), 591-602.

Piggin, C. L., Roden, D. L., Law, A. M., Molloy, M. P., Krisp, C., Swarbrick, A., ... & Ormandy, C. J. (2020). ELF5 modulates the estrogen receptor cistrome in breast cancer. PLoS genetics, 16(1), e1008531.

Swahn, H., Sabith Ebron, J., Lamar, K. M., Yin, S., Kerschner, J. L., NandyMazumdar, M., ... & Harris, A. (2019). Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region. Journal of cellular and molecular medicine, 23(11), 7726-7740.

Omata, F., McNamara, K. M., Suzuki, K., Abe, E., Hirakawa, H., Ishida, T., ... & Sasano, H. (2018). Effect of the normal mammary differentiation regulator ELF5 upon clinical outcomes of triple negative breast cancers patients. Breast Cancer, 25(4), 489-496.

Luk, I. Y., Reehorst, C. M., & Mariadason, J. M. (2018). ELF3, ELF5, EHF and SPDEF transcription factors in tissue homeostasis and cancer. Molecules, 23(9), 2191.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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