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Mouse Anti-ELOVL5 Recombinant Antibody (CBFYE-0804) (CBMAB-E1252-FY)

This product is mouse antibody that recognizes ELOVL5. The antibody CBFYE-0804 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all ELOVL5 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
CBFYE-0804
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ELOVL Fatty Acid Elongase 5
Introduction
This gene belongs to the ELO family. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum. This protein is involved in the elongation of long-chain polyunsaturated fatty acids. Mutations in this gene have been associated with spinocerebellar ataxia-38 (SCA38). Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
Rat171400
Mouse68801
UniProt ID
RatD4A9V6
MouseQ920L7
Alternative Names
HELO1; AI747313; AU043003; 1110059L23Rik
Research Area
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity) (PubMed:10970790, PubMed:20937905).

In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (By similarity).
Biological Process
Alpha-linolenic acid metabolic process Source: Reactome
Fatty acid elongation, monounsaturated fatty acid Source: UniProtKB
Fatty acid elongation, polyunsaturated fatty acid Source: UniProtKB
Fatty acid elongation, saturated fatty acid Source: GO_Central
Linoleic acid metabolic process Source: Reactome
Long-chain fatty-acyl-CoA biosynthetic process Source: Reactome
Positive regulation of fatty acid biosynthetic process Source: BHF-UCL
Sphingolipid biosynthetic process Source: GO_Central
Unsaturated fatty acid biosynthetic process Source: UniProtKB-UniRule
Very long-chain fatty acid biosynthetic process Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane; Dendrite. In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree.
Involvement in disease
Spinocerebellar ataxia 38 (SCA38):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA38 is an autosomal dominant form characterized by adult-onset of slowly progressive gait ataxia accompanied by nystagmus. Brain MRI shows cerebellar atrophy.

Kieu, T. L. V., Pierre, L., Derangère, V., Perrey, S., Truntzer, C., Jalil, A., ... & Rialland, M. (2022). Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-β receptors. Cell death & disease, 13(9), 1-18.

Li, Y., Tocher, D. R., Pang, Y., Du, J., Xiang, X., Mai, K., & Ai, Q. (2022). Environmental adaptation in fish induced changes in the regulatory region of fatty acid elongase gene, elovl5, involved in long-chain polyunsaturated fatty acid biosynthesis. International Journal of Biological Macromolecules, 204, 144-153.

Nitta, S., Kandori, S., Tanaka, K., Sakka, S., Siga, M., Nagumo, Y., ... & Nishiyama, H. (2022). ELOVL5‐mediated fatty acid elongation promotes cellular proliferation and invasion in renal cell carcinoma. Cancer science, 113(8), 2738.

Balbo, I., Montarolo, F., Genovese, F., Tempia, F., & Hoxha, E. (2022). Effects of the administration of Elovl5-dependent fatty acids on a spino-cerebellar ataxia 38 mouse model. Behavioral and Brain Functions, 18(1), 1-10.

Zhao, L., Li, F., Liu, T., Yuan, L., Zhang, X., Zhang, D., ... & Wang, W. (2022). Ovine ELOVL5 and FASN genes polymorphisms and their correlations with sheep tail fat deposition. Gene, 807, 145954.

Centenera, M. M., Scott, J. S., Machiels, J., Nassar, Z. D., Miller, D. C., Zinonos, I., ... & Butler, L. M. (2021). ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate CancerTargeting ELOVL5 in Prostate Cancer. Cancer research, 81(7), 1704-1718.

Hoxha, E., Balbo, I., Parolisi, R., Audano, M., Montarolo, F., Ravera, F., ... & Tempia, F. (2021). Elovl5 is required for proper action potential conduction along peripheral myelinated fibers. Glia, 69(10), 2419-2428.

Sun, S., Ren, T., Li, X., Cao, X., & Gao, J. (2020). Polyunsaturated fatty acids synthesized by freshwater fish: A new insight to the roles of elovl2 and elovl5 in vivo. Biochemical and Biophysical Research Communications, 532(3), 414-419.

Losol, P., Rezwan, F. I., Patil, V. K., Venter, C., Ewart, S., Zhang, H., ... & Holloway, J. W. (2019). Effect of gestational oily fish intake on the risk of allergy in children may be influenced by FADS1/2, ELOVL5 expression and DNA methylation. Genes & Nutrition, 14(1), 1-7.

Shi, H. B., Du, Y., Zhang, C. H., Sun, C., He, Y. L., Wu, Y. H., ... & Loor, J. J. (2018). Fatty acid elongase 5 (ELOVL5) alters the synthesis of long-chain unsaturated fatty acids in goat mammary epithelial cells. Journal of dairy science, 101(5), 4586-4594.

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For research use only. Not intended for any clinical use.

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