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Rabbit Anti-EMC4 Recombinant Antibody (CBYJT-1221) (CBMAB-T0236-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to EMC4 (ER Membrane Protein Complex Subunit 4). The antibody can be used for immunoassay techniques, such as WB, IP, IHC-P.
See all EMC4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Rat, Mouse
Clone
CBYJT-1221
Antibody Isotype
IgG
Application
WB, IP, IHC-P

Basic Information

Immunogen
Synthetic peptide within Human TMEM85 aa 1-100. The exact sequence is proprietary.
Specificity
Human, Rat, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-100

Target

Full Name
ER Membrane Protein Complex Subunit 4
Introduction
EMC4 (ER Membrane Protein Complex Subunit 4) functions in apoptotic process, protein folding in endoplasmic reticulum
Entrez Gene ID
Human51234
Mouse68032
Rat296049
UniProt ID
HumanQ5J8M3
MouseQ9CZX9
RatD4A0W1
Alternative Names
ER Membrane Protein Complex Subunit 4; Transmembrane Protein 85; Cell Proliferation-Inducing Gene 17 Protein; TMEM85; PIG17
Research Area
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656).

Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231).

Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151).

It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231).

By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835).

By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
Biological Process
Apoptotic process Source: UniProtKB-KW
Protein insertion into ER membrane by stop-transfer membrane-anchor sequence Source: UniProtKB
Tail-anchored membrane protein insertion into ER membrane Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane. Could also be a single-pass transmembrane protein with cytosolic N-terminus and lumenal C-terminus.
Topology
Cytoplasmic: 2-66
Helical: 67-87
Lumenal: 88-98
Helical: 99-120
Cytoplasmic: 121-127
Helical: 128-148
Lumenal: 149-183
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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