Mouse Anti-EMX2 Recombinant Antibody (3C11) (V2LY-0825-LY189)

Name: Mouse Anti-EMX2 Recombinant Antibody (3C11)
SKU: V2LY-0825-LY189
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3C11

Application

ELISA

Immunogen

EMX2 (aa 103-200) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Empty Spiracles Homeobox 2

Entrez Gene ID

2018

UniProt ID

Q04743

Research Area

Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.

Biological Process

Anterior/posterior pattern specification Source: Ensembl
Brain development Source: GO_Central
Cell proliferation in forebrain Source: Ensembl
Central nervous system development Source: GO_Central
Cerebral cortex regionalization Source: Ensembl
Dentate gyrus development Source: Ensembl
Forebrain cell migration Source: Ensembl
Neuron differentiation Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to drug Source: Ensembl
Ureter morphogenesis Source: Ensembl

Cellular Location

Nucleus

Involvement in disease

Schizencephaly (SCHZC):
Extremely rare human congenital disorder characterized by a full-thickness cleft within the cerebral hemispheres. These clefts are lined with gray matter and most commonly involve the parasylvian regions. Large portions of the cerebral hemispheres may be absent and replaced by cerebro-spinal fluid.

Li, H., Liao, S., Luo, G., Li, H., Wang, S., Li, Z., & Luo, X. (2022). An Association between EMX2 Variations and Mayer-Rokitansky-Küster-Hauser Syndrome: A Case-Control Study of Chinese Women. Journal of Healthcare Engineering, 2022.

Nguyen, K., & Wingert, R. (2022). emx2is Required for Nephron Segment Development in the Zebrafish Pronephros. The FASEB Journal, 36.

Jimenez-García, M. P., Lucena-Cacace, A., Otero-Albiol, D., & Carnero, A. (2021). Empty spiracles homeobox genes EMX1 and EMX2 regulate WNT pathway activation in sarcomagenesis. Journal of Experimental & Clinical Cancer Research, 40(1), 1-18.

Jimenez-García, M. P., Lucena-Cacace, A., Otero-Albiol, D., & Carnero, A. (2021). Regulation of sarcomagenesis by the empty spiracles homeobox genes EMX1 and EMX2. Cell death & disease, 12(6), 1-17.

Luo, X., Yang, R., Bai, Y., Li, L., Lin, N., Sun, L., ... & Wu, Z. (2021). Binding of microRNA-135a (miR-135a) to homeobox protein A10 (HOXA10) mRNA in a high-progesterone environment modulates the embryonic implantation factors beta3-integrin (ITGβ3) and empty spiracles homeobox-2 (EMX2). Annals of Translational Medicine, 9(8).

Wang, L., Jin, J., Zhou, Y., Tian, Z., He, B., Huang, Y., & Ding, F. (2019). EMX2 is epigenetically silenced and suppresses epithelial‑mesenchymal transition in human esophageal adenocarcinoma. Oncology Reports, 42(5), 2169-2178.

Wei, X. F., Chen, Q. L., Fu, Y., & Zhang, Q. K. (2019). Wnt and BMP signaling pathways co‐operatively induce the differentiation of multiple myeloma mesenchymal stem cells into osteoblasts by upregulating EMX2. Journal of Cellular Biochemistry, 120(4), 6515-6527.

Groves, J. A., Gillman, C., DeLay, C. N., & Kroll, T. T. (2019). Identification of Novel Binding Partners for Transcription Factor Emx2. The Protein Journal, 38(1), 2-11.

Monnier, A., Boniface, R., Bouvet, R., Etcheverry, A., Aubry, M., Avril, T., ... & Mosser, J. (2018). The expression of EMX2 lead to cell cycle arrest in glioblastoma cell line. BMC cancer, 18(1), 1-11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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