Mouse Anti-EPSTI1 Recombinant Antibody (CBFYE-0247) (V2LY-0825-LY573)

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Basic Information

Host Animal
Mouse
Clone
CBFYE-0247
Application
WB, IP, IF, ELISA, IHC-P
Immunogen
Recombinant human EPSTI1.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, gelatin
Preservative
Sodium azide
Concentration
0.1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
epithelial stromal interaction 1 (breast)
Entrez Gene ID
UniProt ID
Research Area
Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (By similarity).

Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages (By similarity).

Bei, Y. R., Zhang, S. C., Song, Y., Tang, M. L., Zhang, K. L., Jiang, M., ... & Hu, Y. W. (2022). EPSTI1 promotes monocyte adhesion to endothelial cells in vitro via upregulating VCAM-1 and ICAM-1 expression. Acta Pharmacologica Sinica, 1-10.

Adilijiang, K., Zhihua, M., Zhayidan, A., Ayinuerguli, A., Nadire, H., & Abulaiti, A. (2022). Knockdown of EPSTI1 alleviates lipopolysaccharide-induced inflammatory injury through regulation of NF-kB signaling in a cellular pneumonia model. Allergol. immunopatol, 50(3), 106-112.

Sun, J. L., Zhang, H. Z., Liu, S. Y., Lian, C. F., Chen, Z. L., Shao, T. H., ... & Zhang, F. C. (2020). Elevated EPSTI1 promote B cell hyperactivation through NF-κB signalling in patients with primary Sjögren’s syndrome. Annals of the Rheumatic Diseases, 79(4), 518-524.

Fan, M. M., Arai, M., Tawada, A., Chiba, T., Fukushima, R., Uzawa, K., ... & Takiguchi, Y. (2020). Contrasting functions of EPSTI1 in human oral and lung squamous cell cancer cell lines-its tumor promoting roles in oral and tumor suppressing roles in lung squamous cell carcinomas. Cancer Research, 80(16_Supplement), 2580-2580.

Xie, J., Wang, S., Li, G., Zhao, X., Jiang, F., Liu, J., & Tan, W. (2019). circEPSTI1 regulates ovarian cancer progression via decoying miR‐942. Journal of cellular and molecular medicine, 23(5), 3597-3602.

Kim, Y. H., Lee, J. R., & Hahn, M. J. (2018). Regulation of inflammatory gene expression in macrophages by epithelial-stromal interaction 1 (Epsti1). Biochemical and biophysical research communications, 496(2), 778-783.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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