Rabbit Anti-ESRRG Recombinant Antibody (L11) (V2LY-0825-LY817)

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Basic Information

Host Animal
Rabbit
Clone
L11
Application
WB
Immunogen
Human ESRRG.
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:1,000-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Estrogen Related Receptor Gamma
Entrez Gene ID
Human2104
Mouse26381
Rat360896
UniProt ID
HumanP62508
MouseP62509
RatP62510
Research Area
Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).

Induces the expression of PERM1 in the skeletal muscle.
Biological Process
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Retinoic acid receptor signaling pathway Source: InterPro
Cellular Location
Nucleus
PTM
Acetylated by PCAF/KAT2 (in vitro).
Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.
Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.

Field, M. G., Kuznetsoff, J. N., Zhang, M. G., Dollar, J. J., Durante, M. A., Sayegh, Y., ... & Harbour, J. W. (2022). RB1 loss triggers dependence on ESRRG in retinoblastoma. Science advances, 8(33), eabm8466.

Zou, Z., Harris, L. K., Forbes, K., & Heazell, A. E. (2022). Placental expression of Estrogen related receptor gamma (ESRRG) is reduced in FGR pregnancies and is mediated by hypoxia. Biology of reproduction.

Liang, Y., Chen, Y., Tian, T., Zhu, S., & Song, K. (2022). Molecular mechanism of the ESRRG-PERM1-CKMT2 signal axis in ovariectomized female rats with OSAHS. Transplant Immunology, 74, 101631.

Zou, Z., Forbes, K., Harris, L. K., & Heazell, A. E. (2021). The potential role of the ESRRG pathway in placental dysfunction. Reproduction, 161(3), R45-R60.

Li, W., Gong, M., Park, Y. P., Elshikha, A. S., Choi, S. C., Brown, J., ... & Morel, L. (2021). Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism. JCI insight, 6(14).

Peng, Z., Guan, Q., Luo, J., Deng, W., Liu, J., Yan, R., & Wang, W. (2020). Sophoridine exerts tumor-suppressive activities via promoting ESRRG-mediated β-catenin degradation in gastric cancer. BMC cancer, 20(1), 1-12.

Müller, S., Perdikari, A., Dapito, D. H., Sun, W., Wollscheid, B., Balaz, M., & Wolfrum, C. (2020). ESRRG and PERM1 govern mitochondrial conversion in brite/beige adipocyte formation. Frontiers in endocrinology, 11, 387.

Anelli, G. M., Mandò, C., Letizia, T., Mazzocco, M. I., Novielli, C., Lisso, F., ... & Cetin, I. (2019). Placental ESRRG-CYP19A1 expressions and circulating 17-beta estradiol in IUGR pregnancies. Frontiers in pediatrics, 7, 154.

Shen, Z., Hu, Y., Zhou, C., Yuan, J., Xu, J., Hao, W., ... & Ye, D. (2019). ESRRG promoter hypermethylation as a diagnostic and prognostic biomarker in laryngeal squamous cell carcinoma. Journal of Clinical Laboratory Analysis, 33(6), e22899.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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