Mouse Anti-F2RL1 Recombinant Antibody (CBXF-2294) (V2LY-0825-LY1102)

F2R Like Trypsin Receptor 1

Bblood coagulation Source: InterPro
Cell-cell junction maintenance Source: UniProtKB
Defense response to virus Source: UniProtKB
Establishment of endothelial barrier Source: UniProtKB
G protein-coupled receptor signaling pathway Source: UniProtKB
Inflammatory response Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Leukocyte migration Source: UniProtKB
Leukocyte proliferation Source: UniProtKB
Mature conventional dendritic cell differentiation Source: UniProtKB
Negative regulation of chemokine production Source: UniProtKB
Negative regulation of JNK cascade Source: UniProtKB
Negative regulation of toll-like receptor 3 signaling pathway Source: UniProtKB
Negative regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Neutrophil activation Source: UniProtKB
Positive regulation of actin filament depolymerization Source: UniProtKB
Positive regulation of cell migration Source: UniProtKB
Positive regulation of chemokine production Source: UniProtKB
Positive regulation of chemotaxis Source: UniProtKB
Positive regulation of cytokine production involved in immune response Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: GO_Central
Positive regulation of eosinophil degranulation Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of glomerular filtration Source: UniProtKB
Positive regulation of GTPase activity Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of interleukin-10 production Source: UniProtKB
Positive regulation of interleukin-1 beta production Source: UniProtKB
Positive regulation of interleukin-6 production Source: UniProtKB
Positive regulation of interleukin-8 production Source: UniProtKB
Positive regulation of JNK cascade Source: UniProtKB
Positive regulation of leukocyte chemotaxis Source: BHF-UCL
Positive regulation of neutrophil mediated killing of gram-negative bacterium Source: UniProtKB
Positive regulation of phagocytosis, engulfment Source: UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
Positive regulation of positive chemotaxis Source: BHF-UCL
Positive regulation of pseudopodium assembly Source: UniProtKB
Positive regulation of renin secretion into blood stream Source: UniProtKB
Positive regulation of Rho protein signal transduction Source: UniProtKB
Positive regulation of superoxide anion generation Source: UniProtKB
Positive regulation of toll-like receptor 2 signaling pathway Source: UniProtKB
Positive regulation of toll-like receptor 3 signaling pathway Source: UniProtKB
Positive regulation of toll-like receptor 4 signaling pathway Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of blood coagulation Source: BHF-UCL
Regulation of chemokine (C-X-C motif) ligand 2 production Source: UniProtKB
Regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Regulation of JNK cascade Source: UniProtKB
T cell activation involved in immune response Source: UniProtKB
Vasodilation Source: UniProtKB

Cell membrane

Extracellular: 37-71
Helical: 72-101
Cytoplasmic: 102-108
Helical: 109-137
Extracellular: 138-149
Helical: 150-177
Cytoplasmic: 178-183
Helical: 184-211
Extracellular: 212-235
Helical: 236-269
Cytoplasmic: 270-277
Helical: 278-317
Extracellular: 318-323
Helical: 324-347
Cytoplasmic: 348-397

A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand (PubMed:10831593, PubMed:19864598, PubMed:9020112, PubMed:10805786, PubMed:16478888). Activating serine proteases include trypsin, mast cell tryptase, coagulation factors VII and Xa, myeloblastin/PRTN3 and membrane-type serine protease 1/ST14 (PubMed:10831593, PubMed:19864598, PubMed:9020112, PubMed:10805786, PubMed:16478888, PubMed:23202369). Subsequent cleavage by serine proteases, including neutrophil elastase and cathepsin G, leads to receptor deactivation (PubMed:12594060). At least in part, implicated proteases are also shown to activate the receptor; the glycosylation status of the receptor is thought to contribute to the difference (PubMed:12171601). In addition to conventional trypsin-like proteases activated by other proteases and glycosidases derived from bacteria, fungi and insects (PubMed:11447194, PubMed:11441110, PubMed:17404307, PubMed:18474671, PubMed:19864598). Activated by serine protease allergens such as dust mite Der p3 and Der p9 and mold Pen c13 (PubMed:11441110, PubMed:17404307). Activated by P.gingivalis arginine-specific (trypsin-like) cysteine proteinases called gingipains (PubMed:11447194). Activated by S.griseus exogenous chitinase (PubMed:18474671). Activated by A.alternata aspartate protease; the cleavage generates non-conventional processed forms (PubMed:19864598).
N-glycosylated and sialylated.
Multiple phosphorylated on serine and threonine residues in the cytoplasmic region upon receptor activation.
Monoubiquitinated by CBL at the plasma membrane and in early endosomes; not required for receptor endocytosis but for translocation to late endosomes or lysosomes. Deubiquitination involves STAMBP and USP8; required for lysosomal trafficking and receptor degradation.