Mouse Anti-FAM3A Recombinant Antibody (CBXF-2563) (V2LY-0825-LY1331)

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Basic Information

Host Animal
Mouse
Clone
CBXF-2563
Application
WB, IHC-P, FC
Immunogen
Recombinant protein within human fam3a (aa 1-230).
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:2,000-1:5,000
IHC-P1:50-1:200
FC1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, glycerol, BSA
Preservative
Sodium azide
Concentration
2 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Family With Sequence Similarity 3 Member A
Entrez Gene ID
Human60343
Mouse66294
UniProt ID
HumanP98173
MouseQ9D8T0
Research Area
May act as a defensin against invading fungal microorganisms.
Biological Process
Antifungal humoral response Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Negative regulation of antifungal innate immune response Source: UniProtKB
Negative regulation of gluconeogenesis Source: InterPro
Regulation of lipid biosynthetic process Source: InterPro
Cellular Location
Secreted

Abdi Ardekani, M., Banaei Far, A. A., Arshadi, S., & Abednatanzi, H. (2022). Effect of High Intensity Interval Training and Thyme Honey on Hepatic miR-423-5P, FAM3A, Akt2 Pathway of Type ll Diabetic rats. medical journal of mashhad university of medical sciences, 65(1).

Liu, X., Hou, S., Xiang, R., Hu, C., Chen, Z., Li, N., ... & Yang, J. (2022). Imipramine activates FAM3A-FOXA2-CPT2 pathway to ameliorate hepatic steatosis. Metabolism, 136, 155292.

Yan, H., Chen, Z., Zhang, H., Yang, W., Liu, X., Meng, Y., ... & Yang, J. (2022). Intracellular ATP signaling contributes to FAM3A-induced PDX1 upregulation in pancreatic Beta cells. Experimental and Clinical Endocrinology & Diabetes, 130(08), 498-508.

Song, Q., Gao, Q., Chen, T., Wen, T., Wu, P., Luo, X., & Chen, Q. Y. (2021). FAM3A Ameliorates Brain Impairment Induced by Hypoxia–Ischemia in Neonatal Rat. Cellular and Molecular Neurobiology, 1-14.

Xiang, R., Chen, J., Li, S., Yan, H., Meng, Y., Cai, J., ... & Yang, J. (2020). VSMC-specific deletion of FAM3A attenuated Ang II-promoted hypertension and cardiovascular hypertrophy. Circulation Research, 126(12), 1746-1759.

Liu, J., An, P., Xue, Y., Che, D., Liu, X., Zheng, J., ... & Yu, B. (2019). Mechanism of Snhg8/miR-384/Hoxa13/FAM3A axis regulating neuronal apoptosis in ischemic mice model. Cell Death & Disease, 10(6), 1-13.

Sala, D., Cunningham, T. J., Stec, M. J., Etxaniz, U., Nicoletti, C., Dall’Agnese, A., ... & Sacco, A. (2019). The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration. Nature communications, 10(1), 1-16.

Yan, S., Jiang, C., Li, H., Li, D., & Dong, W. (2019). FAM3A protects chondrocytes against interleukin-1β-induced apoptosis through regulating PI3K/Akt/mTOR pathway. Biochemical and biophysical research communications, 516(1), 209-214.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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