Rabbit Anti-FAM50A Recombinant Antibody (CBXF-1106) (CBMAB-F0792-CQ)

Name: Rabbit Anti-FAM50A Recombinant Antibody (CBXF-1106)
SKU: CBMAB-F0792-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXF-1106

Application

WB, IF, IHC, FC

Immunogen

Synthetic peptide within human fam50a (aa 1-50).

Host Species

Rabbit

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000
IF(ICC)	1:50-1:100
IHC	1:200-1:400
FC	1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, glycerol, BSA

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

family with sequence similarity 50, member A

Introduction

This gene belongs to the FAM50 family. The encoded protein is highly conserved in length and sequence across different species. It is a basic protein containing a nuclear localization signal, and may function as a DNA-binding protein or a transcriptional factor.

Entrez Gene ID

Human	9130
Mouse	108160
Rat	293862

UniProt ID

Human	Q14320
Mouse	Q9WV03
Rat	B5DF16

Alternative Names

Family With Sequence Similarity 50 Member A; Protein XAP-5; DXS9928E; HXC26; XAP5; DNA Segment On Chromosome X (Unique) 9928 Expressed Sequence;

Research Area

Probably involved in the regulation of pre-mRNA splicing.

Biological Process

Chromatin organization Source: GO_Central
mRNA processing Source: UniProtKB-KW
Regulation of RNA splicing Source: UniProtKB
RNA splicing Source: UniProtKB-KW
Spermatogenesis Source: UniProtKB

Cellular Location

Nucleus

Involvement in disease

Intellectual developmental disorder, X-linked, syndromic, Armfield type (MRXSA):
An X-linked recessive disorder characterized by global developmental delay with impaired intellectual development, walking difficulties and poor or absent speech. Affected individuals display a distinctive phenotype characterized by postnatal growth retardation, variable head circumference with a prominent forehead and dysmorphic facial features, ocular abnormalities, and seizures.

Lee, Y. R., Khan, K., Armfield-Uhas, K., Srikanth, S., Thompson, N. A., Pardo, M., ... & Schwartz, C. E. (2020). Mutations in FAM50A suggest that Armfield XLID syndrome is a spliceosomopathy. Nature communications, 11(1), 1-17.

Kim, Y., Hur, S. W., Jeong, B. C., Oh, S. H., Hwang, Y. C., Kim, S. H., & Koh, J. T. (2018). The Fam50a positively regulates ameloblast differentiation via interacting with Runx2. Journal of Cellular Physiology, 233(2), 1512-1522.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-FAM50A Recombinant Antibody (5F10) (CAT#: CBMAB-A2824-LY)

Rabbit Anti-FAM50A Recombinant Antibody (CBXF-1105) (CAT#: V2LY-0825-LY1348)

Mouse Anti-FAM50A Recombinant Antibody (CBXF-0278) (CAT#: CBMAB-F0275-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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