Mouse Anti-FBXO2 Recombinant Antibody (CBXF-1243) (V2LY-0925-LY421)

Go to compare Compare Online Inquiry
Published Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBXF-1243
Application
WB, IP, IF, ELISA
Immunogen
Amino acids 140-171 within an internal region of human FBXO2.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium azide
Concentration
0.2 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
F-box protein 2
Entrez Gene ID
Human26232
Mouse230904
Rat85273
UniProt ID
HumanQ9UK22
MouseQ80UW2
RatQ9Z1X8
Research Area
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).
Biological Process
Cellular protein modification process Source: ProtInc
Glycoprotein catabolic process Source: UniProtKB
Negative regulation of cell population proliferation Source: Ensembl
Protein ubiquitination Source: UniProtKB
Proteolysis Source: ProtInc
Regulation of protein ubiquitination Source: Ensembl
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Ubiquitin-dependent ERAD pathway Source: GO_Central
Cellular Location
Cytoplasm; Microsome membrane

Ji, J., Shen, J., Xu, Y., Xie, M., Qian, Q., Qiu, T., ... & Liu, B. (2022). FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development. Cell death & disease, 13(5), 1-9.

Buehler, M., Yi, X., Ge, W., Blattmann, P., Rushing, E., Reifenberger, G., ... & Weiss, T. (2022). Quantitative proteomic landscapes of primary and recurrent glioblastoma reveal a protumorigeneic role for FBXO2-dependent glioma-microenvironment interactions. Neuro-oncology.

Yamada, A., Hikichi, M., Nozawa, T., & Nakagawa, I. (2021). FBXO2/SCF ubiquitin ligase complex directs xenophagy through recognizing bacterial surface glycan. EMBO reports, 22(11), e52584.

Wong, S. Y., Lu, P., Wu, L., Montgomery, M., Chowanadisai, W., Lucas, E., ... & Lin, D. (2020). Hepatic F-box Only Protein 2 (FBXO2) Might Not Mediate Glucose Homeostasis in Obese Diabetic Mice. Current Developments in Nutrition, 4(Supplement_2), 1281-1281.

Liu, E. A., Schultz, M. L., Mochida, C., Chung, C., Paulson, H. L., & Lieberman, A. P. (2020). Fbxo2 mediates clearance of damaged lysosomes and modifies neurodegeneration in the Niemann-Pick C brain. JCI insight, 5(20).

Che, X., Jian, F., Wang, Y., Zhang, J., Shen, J., Cheng, Q., ... & Feng, W. (2020). FBXO2 promotes proliferation of endometrial cancer by ubiquitin-mediated degradation of FBN1 in the regulation of the cell cycle and the autophagy pathway. Frontiers in cell and developmental biology, 8, 843.

Zhao, X., Guo, W., Zou, L., & Hu, B. (2020). FBXO2 modulates STAT3 signaling to regulate proliferation and tumorigenicity of osteosarcoma cells. Cancer cell international, 20(1), 1-9.

Wei, X., Bu, J., Mo, X., Lv, B., Wang, X., & Hou, B. (2018). The prognostic significance of FBXO2 expression in colorectal cancer. International Journal of Clinical and Experimental Pathology, 11(10), 5054.

Zhang, H. J., Tian, J., Qi, X. K., Xiang, T., He, G. P., Zhang, H., ... & Feng, L. (2018). Epstein-Barr virus activates F-box protein FBXO2 to limit viral infectivity by targeting glycoprotein B for degradation. PLoS pathogens, 14(7), e1007208.

Sun, X., Wang, T., Guan, Z. R., Zhang, C., Chen, Y., Jin, J., & Hua, D. (2018). FBXO2, a novel marker for metastasis in human gastric cancer. Biochemical and biophysical research communications, 495(3), 2158-2164.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-FBXO2 Recombinant Antibody (CBXF-1243)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.