Mouse Anti-FCRL4 Recombinant Antibody (CBXF-1991) (V2LY-0925-LY1116)

Name: Mouse Anti-FCRL4 Recombinant Antibody (CBXF-1991)
SKU: V2LY-0925-LY1116
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-1991

Application

FC, IHC

Immunogen

FCRL4/FcRH4/IRTA1-transfected cells.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

Application	Note
FC	2-5 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fc Receptor Like 4

Entrez Gene ID

83417

UniProt ID

Q96PJ5

Research Area

May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.

Biological Process

Adaptive immune response Source: UniProtKB-KW
Cell surface receptor signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Involvement in disease

A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).
A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.

Topology

Extracellular: 20-387
Helical: 388-408
Cytoplasmic: 409-515

PTM

Phosphorylated on cytoplasmic tyrosines upon activation.

Liu, Y. (2022). Investigating the role of FcRL4$^+$ B cells at the site of epithelial inflammation (Doctoral dissertation, University of Birmingham).

Liu, Y., Goroshko, S., Leung, L. Y., Dong, S., Khan, S., Campisi, P., ... & Ehrhardt, G. R. (2020). FCRL4 is an Fc receptor for systemic IgA, but not mucosal secretory IgA. The Journal of Immunology, 205(2), 533-538.

Liu, Y., McDaniel, J. R., Khan, S., Campisi, P., Propst, E. J., Holler, T., ... & Ehrhardt, G. R. (2018). Antibodies encoded by FCRL4-bearing memory B cells preferentially recognize commensal microbial antigens. The Journal of Immunology, 200(12), 3962-3969.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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