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Rabbit Anti-FGFR1 (phospho Y653) Recombinant Antibody (BA0355) (CBMAB-0296CQ)

This product is a rabbit antibody that recognizes FGFR1 (phospho Y653) . The antibody BA0355 can be used for immunoassay techniques such as: WB, IHC-P.
See all FGFR1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
BA0355
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Immunogen
Synthetic peptide within Human FGFR1 aa 600-700 (phospho Y653) (Cysteine residue)
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, FGFR family members differ from one another in their ligand affinities and tissue distribution. This splice variant, termed FGFR1-prime, is expressed in human lung fibroblasts and several other human cell lines. The 2 classes of sequences for recognition and splicing of pre-mRNA in eukaryotes, GT-AG and AT-AC, are characterized by the nearly invariant dinucleotides present at the extreme 5-prime (donor) and 3-prime (acceptor) ends of the intron.The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. The FGFR1-prime variant bound specifically to acidic FGF but ligand binding caused neither receptor autophosphorylation nor activation of phospholipase C (PLC). The authors suggested that the kinase-deficient variant may have an important role in regulating cellular responses elicited by acidic FGF stimulation.
Entrez Gene ID
Human2260
Mouse14182
UniProt ID
HumanP11362
MouseP16092
Alternative Names
Fibroblast Growth Factor Receptor 1; Basic Fibroblast Growth Factor Receptor 1; Fms-Related Tyrosine Kinase 2; Proto-Oncogene C-Fgr; EC 2.7.10.1; BFGF-R-1; FGFR-1; N-SAM; BFGFR; FGFBR; FLT-2; HBGFR; FLT2; CEK; FLG; Heparin-Binding Growth Factor Receptor; Hydroxyaryl-Protein Kinase; FMS-Like Tyrosine Kinase 2; Fms-Like Tyrosine Kinase 2; FGFR1/PLAG1 Fusion; Pfeiffer Syndrome; CD331 Antigen; EC 2.7.10; HRTFDS; CD331; ECCL; KAL2; HH2; OGD

Zhu, X., Qiu, C., Wang, Y., Jiang, Y., Chen, Y., Fan, L., ... & Yu, L. (2022). FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis. Proceedings of the National Academy of Sciences, 119(26), e2202631119.

Meric-Bernstam, F., Bahleda, R., Hierro, C., Sanson, M., Bridgewater, J., Arkenau, H. T., ... & Goyal, L. (2022). Futibatinib, an irreversible FGFR1–4 inhibitor, in patients with advanced solid tumors harboring FGF/FGFR aberrations: a phase I dose-expansion study. Cancer discovery, 12(2), 402-415.

Hu, Y., Ai, L. S., & Zhou, L. Q. (2021). Prognostic value of FGFR1 expression and amplification in patients with HNSCC: A systematic review and meta-analysis. PloS one, 16(5), e0251202.

Pozdnyakova, O., Orazi, A., Kelemen, K., King, R., Reichard, K. K., Craig, F. E., ... & Wang, S. A. (2021). Myeloid/lymphoid neoplasms associated with eosinophilia and rearrangements of PDGFRA, PDGFRB, or FGFR1 or with PCM1-JAK2. American journal of clinical pathology, 155(2), 160-178.

Servetto, A., Kollipara, R., Formisano, L., Lin, C. C., Lee, K. M., Sudhan, D. R., ... & Arteaga, C. L. (2021). Nuclear FGFR1 regulates gene transcription and promotes antiestrogen resistance in ER+ breast cancer. Clinical Cancer Research, 27(15), 4379-4396.

Baruch, A., Wong, C., Chinn, L. W., Vaze, A., Sonoda, J., Gelzleichter, T., ... & Arora, P. S. (2020). Antibody-mediated activation of the FGFR1/Klothoβ complex corrects metabolic dysfunction and alters food preference in obese humans. Proceedings of the National Academy of Sciences, 117(46), 28992-29000.

Bahleda, R., Meric-Bernstam, F., Goyal, L., Tran, B., He, Y., Yamamiya, I., ... & Arkenau, H. T. (2020). Phase I, first-in-human study of futibatinib, a highly selective, irreversible FGFR1–4 inhibitor in patients with advanced solid tumors. Annals of Oncology, 31(10), 1405-1412.

Li, J., Liu, H., Srivastava, S. P., Hu, Q., Gao, R., Li, S., ... & Kanasaki, K. (2020). Endothelial FGFR1 (fibroblast growth factor receptor 1) deficiency contributes differential fibrogenic effects in kidney and heart of diabetic mice. Hypertension, 76(6), 1935-1944.

Neocleous, V., Fanis, P., Toumba, M., Tanteles, G. A., Schiza, M., Cinarli, F., ... & Phylactou, L. A. (2020). GnRH deficient patients with congenital hypogonadotropic hypogonadism: novel genetic findings in ANOS1, RNF216, WDR11, FGFR1, CHD7, and POLR3A genes in a case series and review of the literature. Frontiers in endocrinology, 11, 626.

Ryan, M. R., Sohl, C. D., Luo, B., & Anderson, K. S. (2019). The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMTMechanisms of V561M FGFR1–Driven Drug Resistance. Molecular Cancer Research, 17(2), 532-543.

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For research use only. Not intended for any clinical use.

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