Mouse Anti-FILIP1L Recombinant Antibody (
4H7G5) (V2LY-0725-LY462)

Name: Mouse Anti-FILIP1L Recombinant Antibody (4H7G5)
SKU: V2LY-0725-LY462
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-FILIP1L Recombinant Antibody (4H7G5) (V2LY-0725-LY462) in WB

Western Blot Positive WB detected in: 293 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate All lanes: FILIP1L antibody at 1:1000 Secondary Goat polyclonal to mouse IgG at 1/50000 dilution Predicted band size: 102 kDa Observed band size: 29, 80, 102, 130 KDa Exposure time:5min

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4H7G5

Application

ELISA, WB

Immunogen

Recombinant Human Filamin A-interacting protein 1-like protein (aa 1-200).

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:1,000-1:5,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, Glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

filamin A interacting protein 1 like

Entrez Gene ID

11259

UniProt ID

Q4L180

Alternative Names

DOC1; DOC-1; GIP90; GIP130

Function

Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.

Biological Process

Protein localization to actin cytoskeleton

Cellular Location

Cytoplasm; Membrane; Nucleus

Jing, R., Hu, C., Qi, T., Yue, J., Wang, G., Zhang, M., ... & Ma, B. (2021). FILIP1L-mediated cell apoptosis, epithelial-mesenchymal transition and extracellular matrix synthesis aggravate posterior capsular opacification. Life Sciences, 286, 120061.

Kwon, M., Rubio, G., Nolan, N., Auteri, P., Volmar, J. A., Adem, A., ... & Libutti, S. K. (2021). FILIP1L loss is a driver of aggressive mucinous colorectal adenocarcinoma and mediates cytokinesis defects through PFDN1. Cancer research, 81(21), 5523.

Roth, K., Coussement, L., Knatko, E. V., Higgins, M., Steyaert, S., Proby, C. M., ... & Dinkova-Kostova, A. T. (2021). Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma. EBioMedicine, 67, 103383.

Cai, S., Wang, P., Xie, T., Li, Z., Li, J., Lan, R., ... & Liu, P. (2020). Histone H4R3 symmetric di-methylation by Prmt5 protects against cardiac hypertrophy via regulation of Filip1L/β-catenin. Pharmacological research, 161, 105104.

Pan, Z., Li, G. F., Sun, M. L., Xie, L., Liu, D., Zhang, Q., ... & Cao, J. L. (2019). MicroRNA-1224 splicing circularRNA-Filip1l in an Ago2-dependent manner regulates chronic inflammatory pain via targeting Ubr5. Journal of Neuroscience, 39(11), 2125-2143.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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