Mouse Anti-FMNL2 Recombinant Antibody (CBXF-0771) (CBMAB-F0441-CQ)

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Basic Information

Host Animal
Mouse
Clone
CBXF-0771
Application
WB, IP, IF, ELISA
Immunogen
Amino acids 461-505 mapping within an internal region of human FMNL2.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
formin-like 2
Introduction
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined.
Entrez Gene ID
UniProt ID
Alternative Names
Formin Like 2; Formin Homology 2 Domain-Containing Protein 2; Formin Homology 2 Domain Containing 2; FHOD2; Formin-Like Protein 2; Formin-Like 2; KIAA1902;
Function
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics.
Biological Process
Cell migration Source: GO_Central
Cortical actin cytoskeleton organization Source: UniProtKB
Cytoskeleton organization Source: UniProtKB
Regulation of cell morphogenesis Source: UniProtKB
Regulation of cell shape Source: GO_Central
Cellular Location
Cytoplasm

Lee, A. J., Raghavan, N. S., Bhattarai, P., Siddiqui, T., Sariya, S., Reyes-Dumeyer, D., ... & Mayeux, R. (2022). FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer’s disease. Acta neuropathologica, 144(1), 59-79.

Katsuno‐Kambe, H., Parton, R. G., Yap, A. S., & Teo, J. L. (2021). Caveolin‐1 influences epithelial collective cell migration via FMNL2 formin. Biology of the Cell, 113(2), 107-117.

Dimchev, V., Lahmann, I., Koestler, S. A., Kage, F., Dimchev, G., Steffen, A., ... & Rottner, K. (2021). Induced Arp2/3 complex depletion increases FMNL2/3 formin expression and filopodia formation. Frontiers in cell and developmental biology, 9, 634708.

Li, J., & Yan, S. (2021). MiR-466 inhibits the progression of severe hepatocellular carcinoma via regulating FMNL2-mediated activation of NF-κB and Wnt/β-catenin pathways. Journal of Oncology, 2021.

Yan, Y., Su, M., & Qin, B. (2020). CircHIPK3 promotes colorectal cancer cells proliferation and metastasis via modulating of miR-1207-5p/FMNL2 signal. Biochemical and biophysical research communications, 524(4), 839-846.

Pfisterer, K., Levitt, J., Lawson, C. D., Marsh, R. J., Heddleston, J. M., Wait, E., ... & Parsons, M. (2020). FMNL2 regulates dynamics of fascin in filopodia. Journal of Cell Biology, 219(5).

Yan, Y., Wang, Z., & Qin, B. (2019). A novel long noncoding RNA, LINC00483 promotes proliferation and metastasis via modulating of FMNL2 in CRC. Biochemical and biophysical research communications, 509(2), 441-447.

Shao, H. J., Li, Q., Shi, T., Zhang, G. Z., & Shao, F. (2019). LINC00707 promotes cell proliferation and invasion of colorectal cancer via miR-206/FMNL2 axis. Eur Rev Med Pharmacol Sci, 23(9), 3749-3759.

Ren, X. L., Qiao, Y. D., Li, J. Y., Li, X. M., Zhang, D., Zhang, X. J., ... & Liang, L. (2018). Cortactin recruits FMNL2 to promote actin polymerization and endosome motility in invadopodia formation. Cancer letters, 419, 245-256.

Chen, F., Zhang, Q., Wang, Y., Wang, S., Feng, S., Qi, L., ... & Ding, C. (2018). KIT, NRAS, BRAF and FMNL2 mutations in oral mucosal melanoma and a systematic review of the literature. Oncology Letters, 15(6), 9786-9792.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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