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Mouse Anti-FMNL2 Recombinant Antibody (CBXF-0771) (CBMAB-F0441-CQ)

This product is a mouse antibody that recognizes FMNL2. The antibody CBXF-0771 can be used for immunoassay techniques such as: ELISA, WB.
See all FMNL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0771
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
formin-like 2
Introduction
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined.
Entrez Gene ID
114793
UniProt ID
Q96PY5
Alternative Names
Formin Like 2; Formin Homology 2 Domain-Containing Protein 2; Formin Homology 2 Domain Containing 2; FHOD2; Formin-Like Protein 2; Formin-Like 2; KIAA1902;
Function
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics.
Biological Process
Cell migration Source: GO_Central
Cortical actin cytoskeleton organization Source: UniProtKB
Cytoskeleton organization Source: UniProtKB
Regulation of cell morphogenesis Source: UniProtKB
Regulation of cell shape Source: GO_Central
Cellular Location
Cytoplasm

Lee, A. J., Raghavan, N. S., Bhattarai, P., Siddiqui, T., Sariya, S., Reyes-Dumeyer, D., ... & Mayeux, R. (2022). FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer’s disease. Acta neuropathologica, 144(1), 59-79.

Katsuno‐Kambe, H., Parton, R. G., Yap, A. S., & Teo, J. L. (2021). Caveolin‐1 influences epithelial collective cell migration via FMNL2 formin. Biology of the Cell, 113(2), 107-117.

Dimchev, V., Lahmann, I., Koestler, S. A., Kage, F., Dimchev, G., Steffen, A., ... & Rottner, K. (2021). Induced Arp2/3 complex depletion increases FMNL2/3 formin expression and filopodia formation. Frontiers in cell and developmental biology, 9, 634708.

Li, J., & Yan, S. (2021). MiR-466 inhibits the progression of severe hepatocellular carcinoma via regulating FMNL2-mediated activation of NF-κB and Wnt/β-catenin pathways. Journal of Oncology, 2021.

Yan, Y., Su, M., & Qin, B. (2020). CircHIPK3 promotes colorectal cancer cells proliferation and metastasis via modulating of miR-1207-5p/FMNL2 signal. Biochemical and biophysical research communications, 524(4), 839-846.

Pfisterer, K., Levitt, J., Lawson, C. D., Marsh, R. J., Heddleston, J. M., Wait, E., ... & Parsons, M. (2020). FMNL2 regulates dynamics of fascin in filopodia. Journal of Cell Biology, 219(5).

Yan, Y., Wang, Z., & Qin, B. (2019). A novel long noncoding RNA, LINC00483 promotes proliferation and metastasis via modulating of FMNL2 in CRC. Biochemical and biophysical research communications, 509(2), 441-447.

Shao, H. J., Li, Q., Shi, T., Zhang, G. Z., & Shao, F. (2019). LINC00707 promotes cell proliferation and invasion of colorectal cancer via miR-206/FMNL2 axis. Eur Rev Med Pharmacol Sci, 23(9), 3749-3759.

Ren, X. L., Qiao, Y. D., Li, J. Y., Li, X. M., Zhang, D., Zhang, X. J., ... & Liang, L. (2018). Cortactin recruits FMNL2 to promote actin polymerization and endosome motility in invadopodia formation. Cancer letters, 419, 245-256.

Chen, F., Zhang, Q., Wang, Y., Wang, S., Feng, S., Qi, L., ... & Ding, C. (2018). KIT, NRAS, BRAF and FMNL2 mutations in oral mucosal melanoma and a systematic review of the literature. Oncology Letters, 15(6), 9786-9792.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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