Mouse Anti-FOXE1 Recombinant Antibody (CBXF-1231) (V2LY-0925-LY2851)

Name: Mouse Anti-FOXE1 Recombinant Antibody (CBXF-1231)
SKU: V2LY-0925-LY2851
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-1231

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 141-164 of human FOXE1.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG3, κ

Clonality

Monoclonal

Application Notes

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium azide

Concentration

0.2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Forkhead Box E1

Entrez Gene ID

2304

UniProt ID

O00358

Function

Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.

Biological Process

Anatomical structure morphogenesis Source: GO_Central
Cell differentiation Source: GO_Central
Cell migration Source: UniProtKB
Cranial skeletal system development Source: Ensembl
Embryonic organ morphogenesis Source: UniProtKB
Hair follicle morphogenesis Source: UniProtKB
Hard palate development Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Pharynx development Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: UniProtKB
Soft palate development Source: UniProtKB
Thymus development Source: UniProtKB
Thyroid gland development Source: UniProtKB
Thyroid hormone generation Source: UniProtKB

Cellular Location

Nucleus

Involvement in disease

Bamforth-Lazarus syndrome (BLS):
A disease characterized by thyroid agenesis, cleft palate and choanal atresia.
Thyroid cancer, non-medullary, 4 (NMTC4):
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.

PTM

Phosphorylated.

Al-Darraji, M. N., Jasim, S. A., Salah Aldeen, O. D. A., Ghasemian, A., & Rasheed, M. (2022). The Effect of LL37 Antimicrobial Peptide on FOXE1 and lncRNA PTCSC 2 Genes Expression in Colorectal Cancer (CRC) and Normal Cells. Asian Pacific Journal of Cancer Prevention, 23(10), 3437-3442.

Acar, S., Gürsoy, S., Arslan, G., Nalbantoğlu, Ö., Hazan, F., Köprülü, Ö., ... & Özkan, B. (2022). Screening of 23 candidate genes by next-generation sequencing of patients with permanent congenital hypothyroidism: novel variants in TG, TSHR, DUOX2, FOXE1, and SLC26A7. Journal of Endocrinological Investigation, 1-14.

Lim, G., Widiapradja, A., Levick, S. P., McKelvey, K. J., Liao, X. H., Refetoff, S., ... & Clifton-Bligh, R. J. (2022). Foxe1 Deletion in the Adult Mouse Is Associated With Increased Thyroidal Mast Cells and Hypothyroidism. Endocrinology, 163(12), bqac158.

Gandarilla-Esparza, D. D., Calleros-Rincón, E. Y., Macias, H. M., González-Delgado, M. F., Vargas, G. G., Sustaita, J. D., ... & Pérez-Morales, R. (2021). FOXE1 polymorphisms and chronic exposure to nitrates in drinking water cause metabolic dysfunction, thyroid abnormalities, and genotoxic damage in women. Genetics and Molecular Biology, 44.

Morillo-Bernal, J., Fernández, L. P., & Santisteban, P. (2020). FOXE1 regulates migration and invasion in thyroid cancer cells and targets ZEB1. Endocrine-Related Cancer, 27(3), 137.

Dai, W., Meng, X., Mo, S., Xiang, W., Xu, Y., Zhang, L., ... & Cai, G. (2020). FOXE1 represses cell proliferation and Warburg effect by inhibiting HK2 in colorectal cancer. Cell Communication and Signaling, 18, 1-13.

Credendino, S. C., Moccia, C., Amendola, E., D’Avino, G., Di Guida, L., Clery, E., ... & De Vita, G. (2020). Foxe1 gene dosage affects thyroid cancer histology and differentiation in vivo. International journal of molecular sciences, 22(1), 25.

Liu, H., Chen, X., Lin, T., Chen, X., Yan, J., & Jiang, S. (2019). MicroRNA‐524‐5p suppresses the progression of papillary thyroid carcinoma cells via targeting on FOXE1 and ITGA3 in cell autophagy and cycling pathways. Journal of cellular physiology, 234(10), 18382-18391.

Ding, Z., Ke, R., Zhang, Y., Fan, Y., & Fan, J. (2019). FOXE1 inhibits cell proliferation, migration and invasion of papillary thyroid cancer by regulating PDGFA. Molecular and cellular endocrinology, 493, 110420.

Ma, J., Huang, X., Li, Z., Shen, Y., Lai, J., Su, Q., ... & Xu, J. (2019). FOXE1 supports the tumor promotion of Gli2 on papillary thyroid carcinoma by the Wnt/β‐catenin pathway. Journal of Cellular Physiology, 234(10), 17739-17748.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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