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Mouse Anti-FOXF2 Recombinant Antibody (CBXF-0838) (CBMAB-F3202-CQ)

This product is a mouse antibody that recognizes FOXF2. The antibody CBXF-0838 can be used for immunoassay techniques such as: S-ELISA, ELISA, WB.
See all FOXF2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBXF-0838
Antibody Isotype
IgG2b, κ
Application
S-ELISA, ELISA, WB

Basic Information

Immunogen
FOXF2 (NP_001443, 346 a.a.-443 a.a) partial recombinant protein with GST tag
Specificity
Human, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Forkhead Box F2
Introduction
FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes.
Entrez Gene ID
Human2295
Rat364707
UniProt ID
HumanQ12947
Alternative Names
Forkhead Box F2; Forkhead-Related Transcription Factor 2; Forkhead-Related Protein FKHL6; Forkhead-Related Activator 2; FREAC-2; FREAC2; FKHL6; Forkhead Box Protein F2; Forkhead-Like 6;
Function
Probable transcription activator for a number of lung-specific genes (PubMed:8626802).

Mediates up-regulation of the E3 ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1 (PubMed:29374064).
Biological Process
Animal organ morphogenesis Source: GO_Central
Embryonic camera-type eye morphogenesis Source: Ensembl
Embryonic digestive tract development Source: Ensembl
Epithelial to mesenchymal transition Source: UniProtKB
Establishment of planar polarity of embryonic epithelium Source: Ensembl
Extracellular matrix organization Source: Ensembl
Genitalia development Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: MGI
Regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Regulation of protein polyubiquitination Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Roof of mouth development Source: UniProtKB
Cellular Location
Nucleus

Ryu, J. R., Ahuja, S., Arnold, C. R., Potts, K. G., Mishra, A., Yang, Q., ... & Childs, S. J. (2022). Stroke-associated intergenic variants modulate a human FOXF2 transcriptional enhancer. Proceedings of the National Academy of Sciences, 119(35), e2121333119.

Jia, D., Zhou, Z., Kwon, O. J., Zhang, L., Wei, X., Zhang, Y., ... & Xin, L. (2022). Stromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity. Nature Communications, 13(1), 6828.

Wu, Q., Li, W., & You, C. (2021). The regulatory roles and mechanisms of the transcription factor FOXF2 in human diseases. PeerJ, 9, e10845.

Lu, J. T., Tan, C. C., Wu, X. R., He, R., Zhang, X., Wang, Q. S., ... & Feng, Y. M. (2020). FOXF2 deficiency accelerates the visceral metastasis of basal-like breast cancer by unrestrictedly increasing TGF-β and miR-182-5p. Cell Death & Differentiation, 27(10), 2973-2987.

He, W., Kang, Y., Zhu, W., Zhou, B., Jiang, X., Ren, C., & Guo, W. (2020). FOXF2 acts as a crucial molecule in tumours and embryonic development. Cell Death & Disease, 11(6), 424.

Liu, L., Chen, G., Chen, T., Shi, W., Hu, H., Song, K., ... & He, Y. (2020). si-SNHG5-FOXF2 inhibits TGF-β1-induced fibrosis in human primary endometrial stromal cells by the Wnt/β-catenin signalling pathway. Stem Cell Research & Therapy, 11, 1-17.

Wang, S., Li, G. X., Tan, C. C., He, R., Kang, L. J., Lu, J. T., ... & Feng, Y. M. (2019). FOXF2 reprograms breast cancer cells into bone metastasis seeds. Nature communications, 10(1), 2707.

Bademci, G., Abad, C., Incesulu, A., Elian, F., Reyahi, A., Diaz-Horta, O., ... & Tekin, M. (2019). FOXF2 is required for cochlear development in humans and mice. Human molecular genetics, 28(8), 1286-1297.

Kang, L. J., Yu, Z. H., Cai, J., He, R., Lu, J. T., Hou, C., ... & Feng, Y. M. (2019). Reciprocal transrepression between FOXF2 and FOXQ1 controls basal‐like breast cancer aggressiveness. The FASEB Journal, 33(5), 6564-6573.

Higashimori, A., Dong, Y., Zhang, Y., Kang, W., Nakatsu, G., Ng, S. S., ... & Yu, J. (2018). Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2–IRF2BPL–β-Catenin Signaling AxisRole of FOXF2 in Gastric Cancer. Cancer research, 78(7), 1643-1656.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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