Mouse Anti-FOXL1 (AA 132-240) Recombinant Antibody (CBXF-3160) (CBMAB-F3856-CQ)

Name: Mouse Anti-FOXL1 (AA 132-240) Recombinant Antibody (CBXF-3160)
SKU: CBMAB-F3856-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-3160

Application

ELISA, IF, IHC, WB

Immunogen

FOXL1 (NP_005241, 132aa-240aa) full length recombinant protein with GST tag

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 132-240

More Infomation

Target

Full Name

Forkhead Box L1

Introduction

This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis.

Entrez Gene ID

2300

UniProt ID

Q12952

Alternative Names

Forkhead Box L1; Forkhead-Related Transcription Factor 7; Forkhead-Related Protein FKHL11; FKHL11; FREAC7; Forkhead Box Protein L1; Forkhead-Like 11; FREAC-7; FKH6;

Function

Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity).

Biological Process

Anatomical structure morphogenesis Source: GO_Central
Cell differentiation Source: GO_Central
Heart development Source: DFLAT
Multicellular organism development Source: UniProtKB
Peyer's patch morphogenesis Source: Ensembl
Proteoglycan biosynthetic process Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of Wnt signaling pathway Source: UniProtKB
Visceral mesoderm-endoderm interaction involved in midgut development Source: UniProtKB

Cellular Location

Nucleus

Zheng, B., Liu, J., Shi, X., Xu, J., Zhang, K., Zhou, H., ... & Guo, Y. (2022). BMI1 governs the maintenance of mouse GC-2 cells through epigenetic repression of Foxl1 transcription. American Journal of Translational Research, 14(5), 3407.

Gehlen, J., Giel, A. S., Köllges, R., Haas, S. L., Zhang, R., Trcka, J., ... & Schumacher, J. (2022). First genome-wide association study of esophageal atresia identifies three genetic risk loci at CTNNA3, FOXF1/FOXC2/FOXL1, and HNF1B. Human Genetics and Genomics Advances, 3(2), 100093.

Abdelfatah, N., Mostafa, A. A., French, C. R., Doucette, L. P., Penney, C., Lucas, M. B., ... & Young, T. L. (2021). A pathogenic deletion in Forkhead Box L1 (FOXL1) identifies the first otosclerosis (OTSC) gene. Human Genetics, 1-15.

Kolev, H. M., Tian, Y., Kim, M. S., Leu, N. A., Adams-Tzivelekidis, S., Lengner, C. J., ... & Kaestner, K. H. (2021). A FoxL1-CreERT-2A-tdTomato mouse labels subepithelial telocytes. Cellular and Molecular Gastroenterology and Hepatology, 12(3), 1155.

Hasebe, T., Fujimoto, K., & Ishizuya-Oka, A. (2020). Thyroid hormone-induced expression of Foxl1 in subepithelial fibroblasts correlates with adult stem cell development during Xenopus intestinal remodeling. Scientific Reports, 10(1), 20715.

Miyashita, N., Horie, M., Suzuki, H. I., Saito, M., Mikami, Y., Okuda, K., ... & Nagase, T. (2020). FOXL1 regulates lung fibroblast function via multiple mechanisms. American Journal of Respiratory Cell and Molecular Biology, 63(6), 831-842.

Luo, D. B., Lv, H. B., Sun, X. H., Wang, Y., Chu, J. H., & Salai, A. L. (2020). LncRNA TRERNA1 promotes malignant progression of NSCLC through targeting FOXL1. Eur Rev Med Pharmacol Sci, 24(3), 1233-1242.

Kaestner, K. H. (2019). The intestinal stem cell niche: a central role for Foxl1-expressing subepithelial telocytes. Cellular and molecular gastroenterology and hepatology, 8(1), 111-117.

Wang, Y. G., Wang, T., Shi, M., & Zhai, B. (2019). Long noncoding RNA EPB41L4A-AS2 inhibits hepatocellular carcinoma development by sponging miR-301a-5p and targeting FOXL1. Journal of Experimental & Clinical Cancer Research, 38(1), 1-13.

Chen, A., Zhong, L., & Lv, J. (2019). FOXL1 overexpression is associated with poor outcome in patients with glioma. Oncology Letters, 18(1), 751-757.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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