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Mouse Anti-FOXL1 (AA 132-240) Recombinant Antibody (CBXF-3160) (CBMAB-F3856-CQ)

This product is a mouse antibody that recognizes FOXL1 (AA 132-240). The antibody CBXF-3160 can be used for immunoassay techniques such as: ELISA, IF, IHC, WB.
See all FOXL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-3160
Antibody Isotype
IgG1, κ
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
FOXL1 (NP_005241, 132aa-240aa) full length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 132-240

Target

Full Name
Forkhead Box L1
Introduction
This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis.
Entrez Gene ID
2300
UniProt ID
Q12952
Alternative Names
Forkhead Box L1; Forkhead-Related Transcription Factor 7; Forkhead-Related Protein FKHL11; FKHL11; FREAC7; Forkhead Box Protein L1; Forkhead-Like 11; FREAC-7; FKH6;
Function
Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity).
Biological Process
Anatomical structure morphogenesis Source: GO_Central
Cell differentiation Source: GO_Central
Heart development Source: DFLAT
Multicellular organism development Source: UniProtKB
Peyer's patch morphogenesis Source: Ensembl
Proteoglycan biosynthetic process Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of Wnt signaling pathway Source: UniProtKB
Visceral mesoderm-endoderm interaction involved in midgut development Source: UniProtKB
Cellular Location
Nucleus

Zheng, B., Liu, J., Shi, X., Xu, J., Zhang, K., Zhou, H., ... & Guo, Y. (2022). BMI1 governs the maintenance of mouse GC-2 cells through epigenetic repression of Foxl1 transcription. American Journal of Translational Research, 14(5), 3407.

Gehlen, J., Giel, A. S., Köllges, R., Haas, S. L., Zhang, R., Trcka, J., ... & Schumacher, J. (2022). First genome-wide association study of esophageal atresia identifies three genetic risk loci at CTNNA3, FOXF1/FOXC2/FOXL1, and HNF1B. Human Genetics and Genomics Advances, 3(2), 100093.

Abdelfatah, N., Mostafa, A. A., French, C. R., Doucette, L. P., Penney, C., Lucas, M. B., ... & Young, T. L. (2021). A pathogenic deletion in Forkhead Box L1 (FOXL1) identifies the first otosclerosis (OTSC) gene. Human Genetics, 1-15.

Kolev, H. M., Tian, Y., Kim, M. S., Leu, N. A., Adams-Tzivelekidis, S., Lengner, C. J., ... & Kaestner, K. H. (2021). A FoxL1-CreERT-2A-tdTomato mouse labels subepithelial telocytes. Cellular and Molecular Gastroenterology and Hepatology, 12(3), 1155.

Hasebe, T., Fujimoto, K., & Ishizuya-Oka, A. (2020). Thyroid hormone-induced expression of Foxl1 in subepithelial fibroblasts correlates with adult stem cell development during Xenopus intestinal remodeling. Scientific Reports, 10(1), 20715.

Miyashita, N., Horie, M., Suzuki, H. I., Saito, M., Mikami, Y., Okuda, K., ... & Nagase, T. (2020). FOXL1 regulates lung fibroblast function via multiple mechanisms. American Journal of Respiratory Cell and Molecular Biology, 63(6), 831-842.

Luo, D. B., Lv, H. B., Sun, X. H., Wang, Y., Chu, J. H., & Salai, A. L. (2020). LncRNA TRERNA1 promotes malignant progression of NSCLC through targeting FOXL1. Eur Rev Med Pharmacol Sci, 24(3), 1233-1242.

Kaestner, K. H. (2019). The intestinal stem cell niche: a central role for Foxl1-expressing subepithelial telocytes. Cellular and molecular gastroenterology and hepatology, 8(1), 111-117.

Wang, Y. G., Wang, T., Shi, M., & Zhai, B. (2019). Long noncoding RNA EPB41L4A-AS2 inhibits hepatocellular carcinoma development by sponging miR-301a-5p and targeting FOXL1. Journal of Experimental & Clinical Cancer Research, 38(1), 1-13.

Chen, A., Zhong, L., & Lv, J. (2019). FOXL1 overexpression is associated with poor outcome in patients with glioma. Oncology Letters, 18(1), 751-757.

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For research use only. Not intended for any clinical use.

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