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Rabbit Anti-FOXO6 Recombinant Antibody (CBXF-1233) (CBMAB-F0966-CQ)

This product is a rabbit antibody that recognizes FOXO6. The antibody CBXF-1233 can be used for immunoassay techniques such as: WB.
See all FOXO6 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXF-1233
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Forkhead Box O6
Introduction
FOXO6 (Forkhead Box O6) is a Protein Coding gene. Among its related pathways are FoxO signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is FOXO3.
Entrez Gene ID
Human100132074
Mouse329934
Rat313558
UniProt ID
HumanA8MYZ6
MouseQ70KY4
RatD3ZV21
Alternative Names
Forkhead Box O6;
Function
Transcriptional activator.
Biological Process
Memory Source: Ensembl
Positive regulation of dendritic spine development Source: ParkinsonsUK-UCL
Regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCL
Cellular Location
Nucleus; Cytoplasm. When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors (By similarity).
PTM
Phosphorylation of Ser-184 is be important in regulating the transacriptional activity.

Zhang, L., Zhang, Y., Zhou, M., Wang, S., Li, T., Hu, Z., & Jin, C. (2021). Role and mechanism underlying FoxO6 in skeletal muscle in vitro and in vivo. International Journal of Molecular Medicine, 48(1), 1-8.

Desai, S., Pansare, P., Sainani, S., Doke, R., Bhalchim, V., & Rode, K. (2020). Foxo6–A Novel Target for Parkinson’s Disease. Biomedical and Pharmacology Journal, 13(1), 367-381.

Jin, A., Zhang, Q., Li, S., & Li, B. (2020). Downregulation of FOXO6 alleviates hypoxia-induced apoptosis and oxidative stress in cardiomyocytes by enhancing Nrf2 activation via upregulation of SIRT6. Journal of bioenergetics and biomembranes, 52(6), 409-419.

Moon, K. M., Lee, B., Kim, D. H., & Chung, H. Y. (2020). FoxO6 inhibits melanogenesis partly by elevating intracellular antioxidant capacity. Redox biology, 36, 101624.

Yu, X., Gao, X., Mao, X., Shi, Z., Zhu, B., Xie, L., ... & Jin, L. (2020). Knockdown of FOXO6 inhibits glycolysis and reduces cell resistance to paclitaxel in HCC cells via PI3K/Akt signaling pathway. OncoTargets and therapy, 13, 1545.

Li, Q., Tang, H., Hu, F., & Qin, C. (2019). Silencing of FOXO6 inhibits the proliferation, invasion, and glycolysis in colorectal cancer cells. Journal of Cellular Biochemistry, 120(3), 3853-3860.

Kim, D. H., Lee, B., Lee, J., Kim, M. E., Lee, J. S., Chung, J. H., ... & Chung, H. Y. (2019). FoxO6-mediated IL-1β induces hepatic insulin resistance and age-related inflammation via the TF/PAR2 pathway in aging and diabetic mice. Redox Biology, 24, 101184.

Sun, Z., da Fontoura, C. S., Moreno, M., Holton, N. E., Sweat, M., Sweat, Y., ... & Amendt, B. A. (2018). FoxO6 regulates Hippo signaling and growth of the craniofacial complex. PLoS genetics, 14(10), e1007675.

Lallemand, F., Petitalot, A., Vacher, S., De Koning, L., Taouis, K., Lopez, B. S., ... & Caputo, S. M. (2018). Involvement of the FOXO6 transcriptional factor in breast carcinogenesis. Oncotarget, 9(7), 7464.

Ye, H., & Duan, M. (2018). Downregulation of FOXO6 in breast cancer promotes epithelial–mesenchymal transition and facilitates migration and proliferation of cancer cells. Cancer management and research, 10, 5145.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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