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Mouse Anti-FRMD3 Recombinant Antibody (CBXF-0906) (CBMAB-F0472-CQ)

This product is a mouse antibody that recognizes FRMD3. The antibody CBXF-0906 can be used for immunoassay techniques such as: ELISA, WB.
See all FRMD3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0906
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FERM domain containing 3
Introduction
The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
257019
UniProt ID
A2A2Y4
Alternative Names
FERM Domain Containing 3; Band 4.1-Like Protein 4O; Ovary Type Protein 4.1; EPB41L4O; 4.1O; FERM Domain-Containing Protein 3;
Function
Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer.
Biological Process
Actomyosin structure organization Source: GO_Central
Cellular Location
Membrane
Topology
Helical: 531-551

Shao, W., Li, J., Piao, Q., Yao, X., Li, M., Wang, S., ... & Sun, L. (2023). FRMD3 inhibits the growth and metastasis of breast cancer through the ubiquitination-mediated degradation of vimentin and subsequent impairment of focal adhesion. Cell Death & Disease, 14(1), 13.

MOHAMMADI, Y., ZANGOOEI, M., SALMANI, F., & FARIMANI, A. R. (2023). Effect of crocin and losartan on biochemical parameters and genes expression of FRMD3 and BMP7 in diabetic rats. Turkish Journal of Medical Sciences, 53(1), 10-18.

Zellinger, B., Bodenhofer, U., Engländer, I. A., Kronberger, C., Grambozov, B., Ruznic, E., ... & Zehentmayr, F. (2022). Hsa-miR-3651 could serve as a novel predictor for in-breast recurrence via FRMD3. Breast Cancer, 1-13.

Wei, Y., Chen, Z., Zhang, R., Wu, B., Lin, L., Zhu, Q., ... & Li, F. (2022). Blood circulating exosomes carrying microRNA-423-5p regulates cell progression in prostate cancer via targeting FRMD3. Journal of Cancer, 13(9), 2970.

Sharif, F., Hassan, M. N., Rehman, H. A., Malik, R., & Safina, S. (2022). Association of Genetic Variants rs1888747 and rs10868025 of FRMD3 Gene with Diabetic Nephropathy in Pakistani Patients. Pakistan Journal of Medical & Health Sciences, 16(12), 684-684.

Chen, T. J., Chou, C. L., Tian, Y. F., Yeh, C. F., Chan, T. C., He, H. L., ... & Lai, H. Y. (2021). High FRMD3 expression is prognostic for worse survival in rectal cancer patients treated with CCRT. International Journal of Clinical Oncology, 26(9), 1689-1697.

Kreepala, C., Panpruang, P., Yodprom, R., Piyajarawong, T., Wattanavaekin, K., Danjittrong, T., & Phuthomdee, S. (2021). Manifestation of rs1888747 polymorphisms in the FRMD3 gene in diabetic kidney disease and diabetic retinopathy in type 2 diabetes patients. Kidney Research and Clinical Practice, 40(2), 263.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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