Mouse Anti-FRMD8 Recombinant Antibody (CBXF-1799) (CBMAB-F3334-CQ)

This product is a mouse antibody that recognizes FRMD8. The antibody CBXF-1799 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all FRMD8 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

CBXF-1799

Antibody Isotype

IgG

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

FERM Domain Containing 8

Introduction

FRMD8 (FERM Domain Containing 8) is a Protein Coding gene. An important paralog of this gene is KRIT1.

Entrez Gene ID

Human	83786
Mouse	67457
Rat	309172

UniProt ID

Human	Q9BZ67
Mouse	Q3UFK8
Rat	Q5U2R3

Alternative Names

FERM Domain Containing 8; FERM Domain-Containing Protein 8; FKSG44;

Function

Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336).

Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019).

Biological Process

Negative regulation of canonical Wnt signaling pathway Source: GO_Central
Positive regulation of tumor necrosis factor production Source: UniProtKB

Cellular Location

Cell membrane; Cytosol

References

Badenes, M., Burbridge, E., Oikonomidi, I., Amin, A., de Carvalho, É., Kosack, L., ... & Adrain, C. (2023). The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth. Life Science Alliance, 6(4).

Künzel, U., Grieve, A. G., Meng, Y., Sieber, B., Cowley, S. A., & Freeman, M. (2018). FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex. Elife, 7, e35012.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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