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Rabbit Anti-FRS3 Recombinant Antibody (EG1244) (CBMAB-EN1504-LY)

The product is antibody recognizes FRS3. The antibody EG1244 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:40000.
See all FRS3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1244
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human FRS3.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fibroblast Growth Factor Receptor Substrate 3
Introduction
This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]
Entrez Gene ID
10817
UniProt ID
O43559
Alternative Names
Fibroblast Growth Factor Receptor Substrate 3; FGFR-Signaling Adaptor SNT2; FGFR Substrate 3; SNT-2; Suc1-Associated Neurotrophic Factor Target 2 (FGFR Signalling Adaptor); Suc1-Associated Neurotrophic Factor Target 2;
Function
Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.
Biological Process
Fibroblast growth factor receptor signaling pathway Source: MGI
Signal transduction Source: ProtInc
Cellular Location
Membrane
PTM
Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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