Mouse Anti-FSHR Recombinant Antibody (CBXF-0932) (CBMAB-F1455-CQ)

Name: Mouse Anti-FSHR Recombinant Antibody (CBXF-0932)
SKU: CBMAB-F1455-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-0932

Application

WB, ICC, IHC-P, IHC-Fr, ELISA

Immunogen

Follicle Stimulating Hormone Receptor

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH7.4, 50% glycerol

Preservative

0.02% sodium azide

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Follicle Stimulating Hormone Receptor

Introduction

The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

2492

UniProt ID

P23945

Alternative Names

Follicle Stimulating Hormone Receptor; Follitropin Receptor; LGR1; Follicle-Stimulating Hormone Receptor; FSH Receptor; FSHR1; FSHRO; FSH-R; ODG1;

Function

G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546).

Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690).

Biological Process

Activation of adenylate cyclase activity Source: GO_Central
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
Cellular response to follicle-stimulating hormone stimulus Source: UniProtKB
Female gamete generation Source: ProtInc
Female gonad development Source: ProtInc
Follicle-stimulating hormone signaling pathway Source: UniProtKB
Gonad development Source: ProtInc
G protein-coupled receptor signaling pathway Source: UniProtKB
Hormone-mediated signaling pathway Source: GO_Central
Male gonad development Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
Regulation of protein kinase A signaling Source: UniProtKB
Spermatogenesis Source: ProtInc

Cellular Location

Cell membrane

Involvement in disease

Ovarian dysgenesis 1 (ODG1):
An autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, poorly developed streak ovaries, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Ovarian hyperstimulation syndrome (OHSS):
Disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis.

Topology

Extracellular: 18-366
Helical: 367-387
Cytoplasmic: 388-398
Helical: 399-421
Extracellular: 422-443
Helical: 444-465
Cytoplasmic: 466-485
Helical: 486-508
Extracellular: 509-528
Helical: 529-550
Cytoplasmic: 551-573
Helical: 574-597
Extracellular: 598-608
Helical: 609-630
Cytoplasmic: 631-695

PTM

Sulfated.
N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.

Duan, J., Xu, P., Zhang, H., Luan, X., Yang, J., He, X., ... & Xu, H. E. (2023). Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature Communications, 14(1), 519.

Surcel, M., Doroftei, B., Neamtiu, I. A., Muresan, D., Caracostea, G., Goidescu, I., ... & Zlatescu-Marton, C. (2022). Impact of Follicle Stimulating Hormone Receptor (FSHR) Polymorphism on the Efficiency of Co-Treatment with Growth Hormone in a Group of Infertile Women from Romania. Diagnostics, 12(10), 2371.

Xia, Y., Wang, Q., He, X. D., Chen, Y., JiGe, M. T., & Zi, X. D. (2020). Cloning and expression analysis of the follicle-stimulating hormone receptor (FSHR) gene in the reproductive axis of female yaks (Bos grunniens). Domestic animal endocrinology, 70, 106383.

Casarini, L., Lazzaretti, C., Paradiso, E., Limoncella, S., Riccetti, L., Sperduti, S., ... & Simoni, M. (2020). Membrane estrogen receptor (GPER) and follicle-stimulating hormone receptor (FSHR) heteromeric complexes promote human ovarian follicle survival. Iscience, 23(12), 101812.

Paschalidou, C., Anagnostou, E., Mavrogianni, D., Raouasnte, R., Klimis, N., Drakakis, P., & Loutradis, D. (2020). The effects of follicle-stimulating hormone receptor (FSHR)-29 and Ser680Asn polymorphisms in IVF/ICSI. Hormone Molecular Biology and Clinical Investigation, 41(2).

Laven, J. S. (2019). Follicle stimulating hormone receptor (FSHR) polymorphisms and polycystic ovary syndrome (PCOS). Frontiers in endocrinology, 10, 23.

Nenonen, H. A., Lindgren, I. A., Prahl, A. S., Trzybulska, D., Kharraziha, I., Hultén, M., ... & Henic, E. (2019). The N680S variant in the follicle-stimulating hormone receptor gene identifies hyperresponders to controlled ovarian stimulation. Pharmacogenetics and Genomics, 29(5), 114.

Nataraja, S., Sriraman, V., & Palmer, S. (2018). Allosteric regulation of the follicle-stimulating hormone receptor. Endocrinology, 159(7), 2704-2716.

Ulloa-Aguirre, A., Zariñán, T., Jardón-Valadez, E., Gutiérrez-Sagal, R., & Dias, J. A. (2018). Structure-function relationships of the follicle-stimulating hormone receptor. Frontiers in endocrinology, 9, 707.

Kim, D., & Johnson, A. L. (2018). Differentiation of the granulosa layer from hen prehierarchal follicles associated with follicle‐stimulating hormone receptor signaling. Molecular reproduction and development, 85(8-9), 729-737.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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