Rabbit Anti-FXR1 Recombinant Antibody (CBXF-2085) (CBMAB-F2023-CQ)

Name: Rabbit Anti-FXR1 Recombinant Antibody (CBXF-2085)
SKU: CBMAB-F2023-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXF-2085

Application

WB, IF

Specificity

Human, Mouse, Rat, Monkey

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

FMR1 Autosomal Homolog 1

Introduction

The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

Human	8087
Mouse	14359
Rat	361927
Monkey	710170

UniProt ID

Human	P51114
Mouse	Q61584
Rat	Q5XI81
Monkey	F6W8C6

Alternative Names

FMR1 Autosomal Homolog 1; Fragile X Mental Retardation, Autosomal Homolog 1; HFXR1p; Fragile X Mental Retardation Autosomal Homolog Variant P5FK; Fragile X Mental Retardation Autosomal Homolog Variant P1K; Fragile X Mental Retardation Autosomal Homolog Variant P2K;

Function

RNA-binding protein required for embryonic and postnatal development of muscle tissue (PubMed:30770808).

May regulate intracellular transport and local translation of certain mRNAs (By similarity).

Biological Process

Apoptotic process Source: ProtInc
Cell differentiation Source: UniProtKB-KW
Muscle organ development Source: UniProtKB
Negative regulation of translation Source: GO_Central
Positive regulation of gene silencing by miRNA Source: UniProtKB
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of response to DNA damage stimulus Source: GO_Central
Positive regulation of translation Source: GO_Central
Regulation of alternative mRNA splicing, via spliceosome Source: GO_Central
Regulation of filopodium assembly Source: GO_Central
Regulation of mRNA stability Source: GO_Central
Skeletal muscle organ development Source: UniProtKB

Cellular Location

Cytosol. Adjacent to Z-lines in muscles.

Involvement in disease

Myopathy, congenital, with respiratory insufficiency and bone fractures (MYORIBF):
An autosomal recessive muscular disorder characterized by severe hypotonia apparent at birth, poor feeding, ulnar deviation of the hands, laterally deviated feet, fractures of the long bones, respiratory insufficiency due to muscle weakness, and death in infancy.
Myopathy, congenital proximal, with minicore lesions (MYOPMIL):
An autosomal recessive, slowly progressive muscular disorder characterized by primarily proximal muscle weakness, neonatal hypotonia leading to delayed motor development, mildly delayed walking in childhood, and difficulty running or climbing. Cardiac function is unaffected, but most patients have obstructive sleep apnea. Muscle biopsy shows type 1 fiber predominance with disorganized Z-lines and minicores that disrupt the myofibrillar striation pattern.

PTM

Arg-445 is dimethylated, probably to asymmetric dimethylarginine.

Shimizu, H., & Hohjoh, H. (2023). FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile X syndrome, are involved in the ubiquitin–proteasome system. Scientific Reports, 13(1), 1956.

Herring, J., Johnson, K., & Richstein, J. (2022). The use of “retardation” in FRAXA, FMRP, FMR1 and other designations. Cells, 11(6), 1044.

Wang, B., Yin, H., Zhang, H., & Wang, T. (2021). circNRIP1 facilitates keloid progression via FXR1‑mediated upregulation of miR‑503‑3p and miR‑503‑5p. International Journal of Molecular Medicine, 47(5), 1-13.

Smith, J. A., Curry, E. G., Blue, R. E., Roden, C., Dundon, S. E., Rodríguez-Vargas, A., ... & Giudice, J. (2020). FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells. Journal of Cell Biology, 219(4).

Khlghatyan, J., Evstratova, A., Bozoyan, L., Chamberland, S., Chatterjee, D., Marakhovskaia, A., ... & Beaulieu, J. M. (2020). Fxr1 regulates sleep and synaptic homeostasis. The EMBO Journal, 39(21), e103864.

Cao, H., Gao, R., Yu, C., Chen, L., & Feng, Y. (2019). The RNA-binding protein FXR1 modulates prostate cancer progression by regulating FBXO4. Functional & integrative genomics, 19, 487-496.

Smith, J. A., Curry, E. G., Blue, R. E., Roden, C., Dundon, S. E., Rodríguez-Vargas, A., ... & Giudice, J. (2019). Regulation of FXR1 by alternative splicing is required for muscle development and controls liquid-like condensates in muscle cells. bioRxiv, 818476.

Nordio, L., Marques, A. T., Lecchi, C., Luciano, A. M., Stefanello, D., & Giudice, C. (2018). Immunohistochemical expression of FXR1 in canine normal tissues and melanomas. Journal of Histochemistry & Cytochemistry, 66(8), 585-593.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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