Rabbit Anti-FXYD6 Recombinant Antibody (CBXF-1067) (CBMAB-F1002-CQ)

This product is a rabbit antibody that recognizes FXYD6. The antibody CBXF-1067 can be used for immunoassay techniques such as: WB, FC, IHC.
See all FXYD6 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

CBXF-1067

Antibody Isotype

IgG

Application

WB, FC, IHC

Basic Information

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

FXYD Domain Containing Ion Transport Regulator 6

Introduction

This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.

Entrez Gene ID

Human	53826
Mouse	59095
Rat	63847

UniProt ID

Human	Q9H0Q3
Mouse	Q9D164
Rat	Q91XV6

Alternative Names

FXYD Domain Containing Ion Transport Regulator 6; Phosphohippolin; FXYD Domain-Containing Ion Transport Regulator 6;

Biological Process

Ion transport Source: UniProtKB-KW
Regulation of sodium ion transmembrane transporter activity Source: GO_Central

Cellular Location

Membrane

Topology

Extracellular: 19-35
Helical: 36-58
Cytoplasmic: 59-95

References

Chen, X., Ding, L., Kong, D., Zhao, X., Liao, L., Zhang, Y., ... & Liu, R. (2020). FXYD6 overexpression in HBV-related hepatocellular carcinoma with cirrhosis. Open Life Sciences, 15(1), 259-266.

Luo, W., Liu, Q., Chen, X., Liu, H., Quan, B., Lu, J., ... & Wang, X. (2021). FXYD6 regulates chemosensitivity by mediating the expression of Na+/K+-ATPase α1 and affecting cell autophagy and apoptosis in colorectal cancer. BioMed Research International, 2021, 1-15.

Xu, S. Y., Xu, P. F., & Gao, T. T. (2018). MiR-372-3p inhibits the growth and metastasis of osteosarcoma cells by targeting FXYD6. Eur Rev Med Pharmacol Sci, 22(1), 62-9.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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