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Mouse Anti-GABRA2 Monoclonal Antibody (S399-19) (CBMAB-1305-YC)

Provided herein is a mouse monoclonal antibody against Human GABRA2. The antibody, clone S399-19, can be used for immunoassay techniques, such as ICC, IF, IHC and WB.
See all GABRA2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
S399-19
Antibody Isotype
IgG1
Application
ICC, IF, IHC, WB

Basic Information

Immunogen
Fusion protein aa 350-385 (Cytoplasmic C-terminus) of rat GABA-A Receptor Alpha2
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Gamma-Aminobutyric Acid Type A Receptor Alpha2 Subunit
Introduction
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho.
Entrez Gene ID
Human2555
Mouse14395
Rat289606
UniProt ID
HumanP47869
MouseP26048
RatP23576
Alternative Names
GABA(A) receptor subunit alpha-2; gamma-aminobutyric acid (GABA) A receptor, alpha 2; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2; gamma-aminobutyric acid receptor A2 subunit
Function
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:29961870, PubMed:31032849).

Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:29961870, PubMed:31032849).

The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity).

The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity).
Biological Process
Chemical synaptic transmission Source: GO_Central
Chloride transmembrane transport Source: GO_Central
Gamma-aminobutyric acid signaling pathway Source: UniProtKB
Inhibitory synapse assembly Source: UniProtKB
Ion transmembrane transport Source: GO_Central
Nervous system process Source: GO_Central
Neurotransmitter transport Source: UniProtKB
Regulation of membrane potential Source: GO_Central
Regulation of neurotransmitter levels Source: UniProtKB
Regulation of postsynaptic membrane potential Source: GO_Central
Signal transduction Source: GO_Central
Synaptic transmission, GABAergic Source: GO_Central
Cellular Location
Postsynaptic cell membrane; Cell membrane; Cytoplasmic vesicle membrane; Dendrite
Involvement in disease
Developmental and epileptic encephalopathy 78 (DEE78):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE78 is an autosomal dominant form characterized by onset of refractory seizures in the first days or months of life. Clinical features include severe developmental delay, hypotonia, microcephaly, cortical visual impairment and profound intellectual disability. Some patients manifest a less severe phenotype characterized by pharmacoresponsive epilepsy, autism spectrum disorder and moderate intellectual disability.
PTM
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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