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Mouse Anti-GABRB1 Recombinant Antibody (CBLG1-459) (CBMAB-G1680-LY)

This product is antibody recognizes GABRB1. The antibody CBLG1-459 immunoassay techniques such as: ICC, IHC-P, IP, WB.
See all GABRB1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Human, Rat
Clone
CBLG1-459
Antibody Isotype
IgG1
Application
ICC, IHC-P, IP, WB

Basic Information

Immunogen
Fusion protein amino acids 327-450 of mouse GABA-A-R-Beta1, accession number P50571
Specificity
Mouse, Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Gamma-Aminobutyric Acid Type A Receptor Beta1 Subunit
Introduction
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia.
Entrez Gene ID
Human2560
Mouse14400
Rat25450
UniProt ID
HumanP18505
MouseP50571
RatP15431
Alternative Names
AW061132; B230208N19Rik; Gabrb-1
Function
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
Biological Process
Cellular response to histamine Source: UniProtKB
Central nervous system neuron development Source: Ensembl
Chemical synaptic transmission Source: GO_Central
Chloride transmembrane transport Source: GO_Central
Gamma-aminobutyric acid signaling pathway Source: UniProtKB
Ion transmembrane transport Source: GO_Central
Ion transport Source: UniProtKB
Nervous system process Source: GO_Central
Ovulation cycle Source: Ensembl
Regulation of membrane potential Source: GO_Central
Response to progesterone Source: Ensembl
Response to toxic substance Source: Ensembl
Signal transduction Source: GO_Central
Cellular Location
Postsynaptic cell membrane; Cell membrane
Involvement in disease
Developmental and epileptic encephalopathy 45 (DEE45):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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