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Mouse Anti-GABRB3 Recombinant Antibody (S87-25) (CBMAB-1548-CN)

This product is a mouse antibody that recognizes GABRB3 of human. The antibody S87-25 can be used for immunoassay techniques such as: WB, IHC.
See all GABRB3 antibodies
Published Data
Fig.2 Primary LEC cultures were stained with rabbit anti-GABA-A R beta 3 antibody.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
S87-25
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Fusion protein corresponding to aa. 370-433 of mouse Beta 3 GABA-A receptor
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% Glycerol
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Gamma-Aminobutyric Acid Type A Receptor Beta3 Subunit
Introduction
This gene encodes a member of the ligand-gated ionic channel family. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism.
Entrez Gene ID
Human2562
Mouse14402
Rat24922
UniProt ID
HumanP28472
MouseP63080
RatP63079
Alternative Names
ECA5; EIEE43
Function
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:18514161, PubMed:22303015, PubMed:26950270, PubMed:22243422, PubMed:24909990).

Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:25489750).

The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity).

The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity (PubMed:25489750).

The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity).

Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286).

Plays an important role in somatosensation and in the production of antinociception (By similarity).
Biological Process
Cellular response to histamine Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Chloride transmembrane transport Source: GO_Central
Gamma-aminobutyric acid signaling pathway Source: UniProtKB
Inhibitory synapse assembly Source: UniProtKB
Ion transmembrane transport Source: GO_Central
Nervous system process Source: GO_Central
Regulation of membrane potential Source: GO_Central
Roof of mouth development Source: UniProtKB
Signal transduction Source: GO_Central
Cellular Location
Postsynaptic cell membrane; Cell membrane; Cytoplasmic vesicle membrane
Involvement in disease
Epilepsy, childhood absence 5 (ECA5):
A subtype of idiopathic generalized epilepsy characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. Tonic-clonic seizures often develop in adolescence. Absence seizures may either remit or persist into adulthood.
Developmental and epileptic encephalopathy 43 (DEE43):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE43 inheritance is autosomal dominant.
Topology
Extracellular: 26-245
Helical: 246-267
Cytoplasmic: 268-270
Helical: 271-293
Extracellular: 294-304
Helical: 305-327
Cytoplasmic: 328-450
Helical: 451-472
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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