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Mouse Anti-GABRD Recombinant Antibody (CBFYH-0220) (CBMAB-H0278-FY)

This product is mouse antibody that recognizes GABRD. The antibody CBFYH-0220 can be used for immunoassay techniques such as: WB, IF, AM.
See all GABRD antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYH-0220
Antibody Isotype
IgG2a
Application
WB, IF, AM

Basic Information

Immunogen
Synthetic peptide amino acids 15-34 of rat GABA-A-R-Delta
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
gamma-aminobutyric acid type A receptor subunit delta
Introduction
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined.
Entrez Gene ID
Human2563
Mouse14403
Rat29689
UniProt ID
HumanO14764
MouseP22933
RatP18506
Alternative Names
Gamma-Aminobutyric Acid Type A Receptor Delta Subunit; Gamma-Aminobutyric Acid (GABA) A Receptor, Delta; GABA(A) Receptor Subunit Delta; GABA(A) Receptor, Delta; Gamma-Aminobutyric Acid Receptor Subunit Delta; GABA-A Receptor, Delta Polypeptide; GEFSP5; EIG10; EJM7
Function
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Biological Process
Chemical synaptic transmission Source: GO_Central
Chloride transmembrane transport Source: GO_Central
Ion transmembrane transport Source: GO_Central
Nervous system process Source: GO_Central
Regulation of membrane potential Source: GO_Central
Signal transduction Source: GO_Central
Cellular Location
Postsynaptic cell membrane; Cell membrane
Involvement in disease
Generalized epilepsy with febrile seizures plus 5 (GEFS+5):
A rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. This disease combines febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
Epilepsy, idiopathic generalized 10 (EIG10):
A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain.
Juvenile myoclonic epilepsy 7 (EJM7):
A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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