Mouse Anti-GAN Recombinant Antibody (CBLG1-515) (V2LY-1225-LY642)

Name: Mouse Anti-GAN Recombinant Antibody (CBLG1-515)
SKU: V2LY-1225-LY642
Rating: 5 (1 reviews)

See all GAN antibodies

Compare Online Inquiry

Published Data

Mouse Anti-GAN Recombinant Antibody (CBLG1-515) (V2LY-1225-LY642) in WB

HILI regulated the interaction between Gigaxonin and TBCB in the HSP90-dependent manner. ...View More

Tan, H., Liao, H., Zhao, L., Lu, Y., Jiang, S., Tao, D., Liu, Y., & Ma, Y. (2017). HILI destabilizes microtubules by suppressing phosphorylation and Gigaxonin-mediated degradation of TBCB. Scientific reports, 7, 46376.

Mouse Anti-GAN Recombinant Antibody (CBLG1-515) (V2LY-1225-LY642) in WB

HILI knockdown promoted the interaction between Gigaxonin and TBCB. ...View More

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLG1-515

Application

WB, IP, IF, ELISA, IHC-P

Immunogen

Amino acids 298-597 mapping at the C-terminus of human Gigaxonin.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Horse, Dog

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
IHC-P	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

0.2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

gigaxonin

Entrez Gene ID

8139

UniProt ID

Q9H2C0

Function

Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.

Biological Process

Cytoskeleton organization Source: InterPro
Protein ubiquitination Source: UniProtKB

Cellular Location

Cytoskeleton; Cytoplasm

Involvement in disease

Giant axonal neuropathy 1, autosomal recessive (GAN1):
A severe autosomal recessive sensorimotor neuropathy affecting both the peripheral nerves and the central nervous system. Axonal loss and the presence of giant axonal swellings filled with neurofilaments on nerve biopsies are the hallmarks of this neurodegenerative disorder.

PTM

Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-GAN Recombinant Antibody (CBLG1-515)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-GAN Recombinant Antibody (CBLG1-515) (CAT#: CBMAB-G1886-LY)

Related Products

Mouse Anti-GAN Recombinant Antibody (4G7) (CAT#: CBMAB-G1885-LY)

Mouse Anti-GAN Recombinant Antibody (4G7) (CAT#: V2LY-1225-LY641)

Mouse Anti-GAN Recombinant Antibody (CBLG1-515) (CAT#: CBMAB-G1886-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry