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Mouse Anti-GATA3 Recombinant Antibody (CBLG1-2604) (CBMAB-G2232-LY)

This product is antibody recognizes GATA3. The antibody CBLG1-2604 immunoassay techniques such as: WB.
See all GATA3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-2604
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 155-443 of human GATA3 (NP_002042) produced in E.coli
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% NaN3
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GATA Binding Protein 3
Introduction
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
Entrez Gene ID
UniProt ID
Alternative Names
GATA Binding Protein 3; GATA-Binding Factor 3; Trans-Acting T-Cell-Specific Transcription Factor GATA-3; GATA-Binding Protein 3; HDRS; HDR;
Function
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity).
Biological Process
Anatomical structure formation involved in morphogenesis Source: UniProtKB
Anatomical structure morphogenesis Source: ProtInc
Aortic valve morphogenesis Source: UniProtKB
Axon guidance Source: Ensembl
Canonical Wnt signaling pathway involved in metanephric kidney development Source: UniProtKB
Cardiac right ventricle morphogenesis Source: UniProtKB
Cell fate commitment Source: GO_Central
Cell fate determination Source: UniProtKB
Cell maturation Source: Ensembl
Cellular response to BMP stimulus Source: Ensembl
Cellular response to interferon-alpha Source: UniProtKB
Cellular response to interleukin-4 Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Chromatin remodeling Source: Ensembl
Cochlea development Source: Ensembl
Defense response Source: ProtInc
Developmental growth Source: Ensembl
Ear development Source: UniProtKB
Embryonic hemopoiesis Source: Ensembl
Embryonic organ development Source: GO_Central
Erythrocyte differentiation Source: Ensembl
Humoral immune response Source: Ensembl
Immune system development Source: GO_Central
Innate immune response Source: UniProtKB-KW
Inner ear morphogenesis Source: Ensembl
In utero embryonic development Source: Ensembl
Kidney development Source: UniProtKB
Lens development in camera-type eye Source: Ensembl
Lymphocyte migration Source: UniProtKB
Male gonad development Source: UniProtKB
Mast cell differentiation Source: Ensembl
Mesenchymal to epithelial transition Source: UniProtKB
Mesonephros development Source: UniProtKB
Negative regulation of cell cycle Source: UniProtKB
Negative regulation of cell motility Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of cell proliferation involved in mesonephros development Source: UniProtKB
Negative regulation of DNA demethylation Source: Ensembl
Negative regulation of endothelial cell apoptotic process Source: UniProtKB
Negative regulation of epithelial to mesenchymal transition Source: BHF-UCL
Negative regulation of fat cell differentiation Source: UniProtKB
Negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation Source: UniProtKB
Negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation Source: UniProtKB
Negative regulation of inflammatory response Source: UniProtKB
Negative regulation of interferon-gamma production Source: Ensembl
Negative regulation of interleukin-2 production Source: Ensembl
Negative regulation of mammary gland epithelial cell proliferation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Nephric duct formation Source: UniProtKB
Nephric duct morphogenesis Source: UniProtKB
Neuron migration Source: Ensembl
Norepinephrine biosynthetic process Source: UniProtKB
Otic vesicle development Source: Ensembl
Parathyroid gland development Source: Ensembl
Parathyroid hormone secretion Source: Ensembl
Pharyngeal system development Source: UniProtKB
Phosphatidylinositol 3-kinase signaling Source: UniProtKB
Positive regulation of endothelial cell migration Source: UniProtKB
Positive regulation of histone H3-K14 acetylation Source: Ensembl
Positive regulation of histone H3-K9 acetylation Source: Ensembl
Positive regulation of interleukin-13 production Source: UniProtKB
Positive regulation of interleukin-4 production Source: UniProtKB
Positive regulation of interleukin-5 production Source: UniProtKB
Positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: UniProtKB
Positive regulation of signal transduction Source: UniProtKB
Positive regulation of T cell differentiation Source: UniProtKB
Positive regulation of T-helper 2 cell cytokine production Source: Ensembl
Positive regulation of thyroid hormone generation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transcription regulatory region DNA binding Source: UniProtKB
Positive regulation of ureteric bud formation Source: UniProtKB
Post-embryonic development Source: Ensembl
Pro-T cell differentiation Source: Ensembl
Regulation of CD4-positive, alpha-beta T cell differentiation Source: Ensembl
Regulation of cellular response to X-ray Source: UniProtKB
Regulation of cytokine production Source: UniProtKB
Regulation of epithelial cell differentiation Source: GO_Central
Regulation of establishment of cell polarity Source: Ensembl
Regulation of histone H3-K27 methylation Source: Ensembl
Regulation of histone H3-K4 methylation Source: Ensembl
Regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
Regulation of neuron apoptotic process Source: Ensembl
Regulation of neuron projection development Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to drug Source: Ensembl
Response to estrogen Source: UniProtKB
Response to ethanol Source: Ensembl
Response to gamma radiation Source: Ensembl
Response to virus Source: UniProtKB
Signal transduction Source: UniProtKB
Sympathetic nervous system development Source: UniProtKB
T cell differentiation Source: MGI
T cell receptor signaling pathway Source: UniProtKB
T-helper 2 cell differentiation Source: Ensembl
Thymic T cell selection Source: Ensembl
Thymus development Source: Ensembl
TOR signaling Source: UniProtKB
Type IV hypersensitivity Source: Ensembl
Ureteric bud formation Source: UniProtKB
Ureter maturation Source: Ensembl
Ureter morphogenesis Source: Ensembl
Uterus development Source: UniProtKB
Ventricular septum development Source: UniProtKB
Cellular Location
Nucleus
Involvement in disease
Hypoparathyroidism, sensorineural deafness, and renal disease (HDR):
A disease characterized by steroid-resistant nephrosis with progressive renal failure, hypoparathyroidism, sensorineural deafness, and renal dysplasia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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