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Mouse Anti-GDF11 (AA 299-407) Recombinant Antibody (CBFYH-0301) (CBMAB-H1172-FY)

This product is mouse antibody that recognizes GDF11. The antibody CBFYH-0301 can be used for immunoassay techniques such as: ICC.
See all GDF11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0301
Antibody Isotype
IgG2b
Application
ICC

Basic Information

Immunogen
E. coli-derived recombinant human GDF-11/BMP-11, Asn299-Ser407
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 299-407

Target

Full Name
Growth Differentiation Factor 11
Introduction
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging.
Entrez Gene ID
UniProt ID
Alternative Names
Growth Differentiation Factor 11; Bone Morphogenetic Protein 11; BMP-11; GDF-11; BMP11; Growth/Differentiation Factor 11
Function
Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues (By similarity).

It is required for proper vertebral patterning and orofacial development (PubMed:31215115).

Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634).
Biological Process
Mesoderm development Source: UniProtKB
Nervous system development Source: UniProtKB
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
Skeletal system development Source: UniProtKB
SMAD protein signal transduction Source: UniProtKB
Cellular Location
Secreted
Involvement in disease
Vertebral hypersegmentation and orofacial anomalies (VHO):
An autosomal dominant disease characterized by supernumerary ribs, supernumerary cervical, thoracic and/or lumbar vertebrae, and orofacial anomalies such as cleft lip with or without cleft palate in most patients.
PTM
Synthesized as large precursor molecule that undergoes proteolytic cleavage by furin-like proteases (PubMed:31215115). This produces an inactive form consisting of the mature C-terminal portion non-covalently bound to its cleaved N-terminal propeptide. Activation of the mature form requires additional cleavage of the propeptide by a tolloid-like metalloproteinase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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