GDF11

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016]
Full Name
Growth Differentiation Factor 11
Function
Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues (By similarity).

It is required for proper vertebral patterning and orofacial development (PubMed:31215115).

Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634).
Biological Process
Mesoderm development Source: UniProtKB
Nervous system development Source: UniProtKB
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
Skeletal system development Source: UniProtKB
SMAD protein signal transduction Source: UniProtKB
Cellular Location
Secreted
Involvement in disease
Vertebral hypersegmentation and orofacial anomalies (VHO):
An autosomal dominant disease characterized by supernumerary ribs, supernumerary cervical, thoracic and/or lumbar vertebrae, and orofacial anomalies such as cleft lip with or without cleft palate in most patients.
PTM
Synthesized as large precursor molecule that undergoes proteolytic cleavage by furin-like proteases (PubMed:31215115). This produces an inactive form consisting of the mature C-terminal portion non-covalently bound to its cleaved N-terminal propeptide. Activation of the mature form requires additional cleavage of the propeptide by a tolloid-like metalloproteinase.
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Anti-GDF11 antibodies

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Mouse Anti-GDF11 Recombinant Antibody (CAP822) (CBMAB-AP2484LY)

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Target: GDF11
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CAP822
Application*: ICC, IHC, IP, WB
Datasheet SDS

Mouse Anti-GDF11 Recombinant Antibody (3G6) (CBMAB-G2697-LY)

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Target: GDF11
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3G6
Application*: E
Datasheet SDS

Mouse Anti-GDF11 Recombinant Antibody (1E11) (CBMAB-G2695-LY)

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Target: GDF11
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E11
Application*: E
Datasheet SDS

Mouse Anti-GDF11 Recombinant Antibody (743835) (CBMAB-G0310-LY)

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Target: GDF11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 743835
Application*: N
Functional Assay
Datasheet SDS

Mouse Anti-GDF11 Recombinant Antibody (743833) (CBMAB-G0309-LY)

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Target: GDF11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 743833
Application*: IH
Datasheet SDS

Mouse Anti-GDF11 (AA 299-407) Recombinant Antibody (CBFYH-0301) (CBMAB-H1172-FY)

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Target: GDF11
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0301
Application*: IC
Datasheet SDS

Mouse Anti-GDF11 (AA 310-407) Recombinant Antibody (CBFYH-0300) (CBMAB-H1171-FY)

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Target: GDF11
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-0300
Application*: E, IH
Datasheet SDS

Mouse Anti-GDF11 Recombinant Antibody (CAP822) (V2LY-1225-LY978)

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Target: GDF11
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CAP822
Application*: WB, IP, E
Datasheet SDS

Mouse Anti-GDF11 Recombinant Antibody (3G6) (V2LY-1225-LY977)

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Target: GDF11
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 3G6
Application*: WB, E
Datasheet SDS

Mouse Anti-GDF11 Recombinant Antibody (1E11) (V2LY-1225-LY976)

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Target: GDF11
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: 1E11
Application*: E, P
Datasheet SDS

Mouse Anti-GDF11 Recombinant Antibody (G0310) (V2LY-1225-LY975)

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Target: GDF11
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: G0310
Application*: E, N, in vivo
In Vivo Assay Functional Assay
Datasheet SDS

Rabbit Anti-GDF11 Recombinant Antibody (G0309) (V2LY-1225-LY974)

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Target: GDF11
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: G0309
Application*: WB, IF, IH
Datasheet SDS

Mouse Anti-GDF11 Recombinant Antibody (CBFYH-0301) (V2LY-1225-LY973)

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Target: GDF11
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0301
Application*: E, F
Datasheet SDS

Mouse Anti-GDF11 Recombinant Antibody (CBFYH-0300) (V2LY-1225-LY972)

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Target: GDF11
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0300
Application*: E, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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