Mouse Anti-GEMIN6 Recombinant Antibody (4H6) (V2LY-1225-LY1058)

Name: Mouse Anti-GEMIN6 Recombinant Antibody (4H6)
SKU: V2LY-1225-LY1058
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-GEMIN6 Recombinant Antibody (4H6) (V2LY-1225-LY1058) in WB

Western blotting for SMN, Gemin2, Ddx20, Gemin6, and α-Tubulin in Control and Nestin-Cre; Ddx20 cKO spinal cords at E13.5. α-Tubulin was used as a loading control. ...View More

Bizen, N., Bepari, A.K., Zhou, L. et al. Ddx20, an Olig2 binding factor, governs the survival of neural and oligodendrocyte progenitor cells via proper Mdm2 splicing and p53 suppression. Cell Death Differ 29, 1028-1041 (2022).

Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4H6

Application

Immunogen

Human GEMIN6.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

0.5 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Gem Nuclear Organelle Associated Protein 6

Entrez Gene ID

79833

UniProt ID

Q8WXD5

Function

The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP.

Biological Process

mRNA splicing, via spliceosome Source: UniProtKB
Spliceosomal complex assembly Source: InterPro
Spliceosomal snRNP assembly Source: UniProtKB

Cellular Location

Nucleoplasm; Gem; Cytoplasm. Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-GEMIN6 Antibody (4H6) (CAT#: CBMAB-1273CQ)

Antibody Pairs

GEMIN6 Matched Antibody Pair (478) (CAT#: APMAB-478LY)

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Mouse Anti-GEMIN6 Antibody (4H6) (CAT#: CBMAB-1273CQ)

Human GEMIN6 ELISA Kit (CAT#: V2LY-0626-LY4611)

Mouse Anti-GEMIN6 Monoclonal Antibody (CBFYH-0316) (CAT#: V2LY-1225-LY1059)

Mouse Anti-GEMIN6 Antibody (2C11) (CAT#: CBMAB-1272CQ)

GEMIN6 Matched Antibody Pair (478) (CAT#: APMAB-478LY)

Mouse Anti-GEMIN6 Recombinant Antibody (2C11) (CAT#: V2LY-1225-LY1057)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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