Rabbit Anti-Gie Antibody (Arl8) (CBMAB-1285CQ)

Name: Rabbit Anti-Gie Antibody (Arl8)
SKU: CBMAB-1285CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

Arl8

Application

IF, IHC, WB

Immunogen

Amino acids 18-186 of Drosophila Arl8 (CG7891)

Specificity

Common fruit fly

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

GTPase indispensable for equal segregation of chromosomes

Introduction

Gie may play a role in lysosome motility and play role in chromosome segregation.

Entrez Gene ID

40961

UniProt ID

Q9VHV5

Alternative Names

Arl8; BcDNA:LD29185; CG7891; Dmel\CG7891; Q9VHV5

Function

Required for normal functioning of the late endocytic pathway including lysosome motility and late endosome-lysosome fusion (PubMed:16537643, PubMed:29940804, PubMed:30115618).

Not required for the delivery of lysosomal membrane protein-containing vesicles to late endosomes (PubMed:29940804).

In larval motorneurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (PubMed:30174114, PubMed:30115618).

Essential role in chromosome segregation (PubMed:15331635).

Biological Process

Anterograde axonal transport Source: UniProtKB
Autophagosome-lysosome fusion Source: FlyBase
Axonal transport Source: UniProtKB
Cell division Source: UniProtKB-KW
Late endosome to lysosome transport Source: UniProtKB
Lysosome localization Source: FlyBase
Neurotransmitter secretion Source: UniProtKB
Presynapse assembly Source: UniProtKB
Protein transport Source: UniProtKB-KW
Response to hypoxia Source: FlyBase
Sister chromatid segregation Source: UniProtKB

Cellular Location

Lysosome membrane; Synapse; Axon; Perikaryon. Localizes the perinuclear region when associated with CG11448.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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