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Rabbit Anti-Gie Antibody (Arl8) (CBMAB-1285CQ)

This product is a rabbit antibody that recognizes Gie. The antibody Arl8 can be used for immunoassay techniques such as: IF, IHC, WB.
See all Gie antibodies

Summary

Host Animal
Rabbit
Specificity
Common fruit fly
Clone
Arl8
Antibody Isotype
IgG
Application
IF, IHC, WB

Basic Information

Immunogen
Amino acids 18-186 of Drosophila Arl8 (CG7891)
Specificity
Common fruit fly
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
GTPase indispensable for equal segregation of chromosomes
Introduction
Gie may play a role in lysosome motility and play role in chromosome segregation.
Entrez Gene ID
40961
UniProt ID
Q9VHV5
Alternative Names
Arl8; BcDNA:LD29185; CG7891; Dmel\CG7891; Q9VHV5
Function
Required for normal functioning of the late endocytic pathway including lysosome motility and late endosome-lysosome fusion (PubMed:16537643, PubMed:29940804, PubMed:30115618).

Not required for the delivery of lysosomal membrane protein-containing vesicles to late endosomes (PubMed:29940804).

In larval motorneurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (PubMed:30174114, PubMed:30115618).

Essential role in chromosome segregation (PubMed:15331635).
Biological Process
Anterograde axonal transport Source: UniProtKB
Autophagosome-lysosome fusion Source: FlyBase
Axonal transport Source: UniProtKB
Cell division Source: UniProtKB-KW
Late endosome to lysosome transport Source: UniProtKB
Lysosome localization Source: FlyBase
Neurotransmitter secretion Source: UniProtKB
Presynapse assembly Source: UniProtKB
Protein transport Source: UniProtKB-KW
Response to hypoxia Source: FlyBase
Sister chromatid segregation Source: UniProtKB
Cellular Location
Lysosome membrane; Synapse; Axon; Perikaryon. Localizes the perinuclear region when associated with CG11448.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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