Gie

May play a role in lysosome motility (PubMed:16537643). Essential role in chromosome segregation.

Full Name

GTPase indispensable for equal segregation of chromosomes

Function

Required for normal functioning of the late endocytic pathway including lysosome motility and late endosome-lysosome fusion (PubMed:16537643, PubMed:29940804, PubMed:30115618).

Not required for the delivery of lysosomal membrane protein-containing vesicles to late endosomes (PubMed:29940804).

In larval motorneurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (PubMed:30174114, PubMed:30115618).

Essential role in chromosome segregation (PubMed:15331635).

Biological Process

Anterograde axonal transport Source: UniProtKB
Autophagosome-lysosome fusion Source: FlyBase
Axonal transport Source: UniProtKB
Cell division Source: UniProtKB-KW
Late endosome to lysosome transport Source: UniProtKB
Lysosome localization Source: FlyBase
Neurotransmitter secretion Source: UniProtKB
Presynapse assembly Source: UniProtKB
Protein transport Source: UniProtKB-KW
Response to hypoxia Source: FlyBase
Sister chromatid segregation Source: UniProtKB

Cellular Location

Lysosome membrane; Synapse; Axon; Perikaryon. Localizes the perinuclear region when associated with CG11448.