Mouse Anti-GJA3 Recombinant Antibody (CBWJC-3723) (V2LY-1225-LY1358)

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Basic Information

Host Animal
Mouse
Clone
CBWJC-3723
Application
WB, IP, IF, ELISA
Immunogen
Amino acids 232-357 mapping within an internal region of mouse connexin 46.
Host Species
Mouse
Specificity
Rat, Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, gelatin
Preservative
Sodium azide
Concentration
0.2 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
gap junction protein alpha 3
Entrez Gene ID
UniProt ID
Function
Structural component of lens fiber gap junctions (PubMed:30044662).

Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells (By similarity).

They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:30044662).
Biological Process
Cell-cell signaling Source: GO_Central
Gap junction-mediated intercellular transport Source: UniProtKB
Visual perception Source: InterPro
Cellular Location
Cell membrane; Gap junction
Involvement in disease
Cataract 14, multiple types (CTRCT14):
An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT14 includes zonular pulverulent cataract, among others. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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