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Mouse Anti-GJA8 Recombinant Antibody (C6) (CBMAB-G3554-LY)

This product is antibody recognizes GJA8. The antibody C6 immunoassay techniques such as: ELISA, IF, IP, WB.
See all GJA8 antibodies
Published Data
Fig.1 Relative fold change in expression of Cxs was examined in data obtained by DNA microarray analysis.
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Fig.2 Left mRNA expression of four Cx genes (Cx37, Cx40, Cx43 and Cx50) was evaluated by TaqMan analysis.
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Fig.3 In western blots, anti-Cx50 antibodies detected a protein of 64 kDa in total homogenate (RTH).
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Fig.4 In Cx50-transfected N2A cells, punctate Cx50 immunoreactivity was found at the cell membrane.
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Summary

Host Animal
Mouse
Specificity
Sheep
Clone
C6
Antibody Isotype
IgM, κ
Application
ELISA, IF, IP, WB

Basic Information

Specificity
Sheep
Antibody Isotype
IgM, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.1% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
gap junction protein, alpha 8, 50kDa
Introduction
This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome. [provided by RefSeq, Dec 2009]
Entrez Gene ID
100170231
UniProt ID
P55917
Function
Structural component of eye lens gap junctions (PubMed:18006672, PubMed:19756179).

Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity).

Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:18006672, PubMed:19756179).
Biological Process
Cell-cell signaling Source: GO_Central
Gap junction-mediated intercellular transport Source: UniProtKB
Lens development in camera-type eye Source: Ensembl
Cellular Location
Cell membrane; Gap junction
Involvement in disease
Cataract 1, multiple types (CTRCT1):
An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT1 includes congenital, zonular pulverulent, nuclear progressive, nuclear pulverulent, nuclear total, total, and posterior subcapsular types of cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes. In some cases cataract is associated with microcornea without any other systemic anomaly or dysmorphism. Microcornea is defined by a corneal diameter inferior to 10 mm in both meridians in an otherwise normal eye.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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