Rabbit Anti-GJB6 Recombinant Antibody (1332) (V2LY-1225-LY1388)

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Published Data
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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rabbit
Clone
1332
Application
WB, IHC-P, IF, IP
Immunogen
Synthetic peptide corresponding to Mouse GJB6 (aa 241-261).
Host Species
Rabbit
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
ApplicationNote
WB1-3 µg/ml
IF(ICC)1:100-1:1,000
IHC-P0.5-1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
0.5 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Gap Junction Protein Beta 6
Entrez Gene ID
UniProt ID
Function
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Biological Process
Aging Source: Ensembl
Apoptotic process Source: Ensembl
Cell-cell signaling Source: GO_Central
Cellular response to glucose stimulus Source: Ensembl
Ear morphogenesis Source: Ensembl
Gap junction assembly Source: ARUK-UCL
Gap junction-mediated intercellular transport Source: ARUK-UCL
Inner ear development Source: Ensembl
Maintenance of blood-brain barrier Source: ARUK-UCL
Negative regulation of cell population proliferation Source: Ensembl
Response to electrical stimulus Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Sensory perception of sound Source: ProtInc
Sinoatrial node development Source: BHF-UCL
Transmembrane transport Source: ARUK-UCL
Cellular Location
Cell membrane; Gap junction
Involvement in disease
Ectodermal dysplasia 2, Clouston type (ECTD2):
A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. ECTD2 is an autosomal dominant condition characterized by atrichosis, nail hypoplasia and deformities, hyperpigmentation of the skin, normal teeth, normal sweat and sebaceous gland function. Palmoplantar hyperkeratosis is a frequent feature. Hearing impairment has been detected in few cases.
Deafness, autosomal recessive, 1B (DFNB1B):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Deafness, autosomal dominant, 3B (DFNA3B):
A form of non-syndromic sensorineural hearing loss characterized by a variable phenotype, ranging from bilateral middle to high frequency hearing loss to profound sensorineural deafness. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Topology
Cytoplasmic: 1-22
Helical: 23-45
Extracellular: 46-75
Helical: 76-98
Cytoplasmic: 99-131
Helical: 132-154
Extracellular: 155-192
Helical: 193-215
Cytoplasmic: 216-261
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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