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Mouse Anti-GLE1 Recombinant Antibody (1D8) (CBMAB-G3693-LY)

This product is antibody recognizes GLE1. The antibody 1D8 immunoassay techniques such as: ELISA, IF, WB.
See all GLE1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D8
Antibody Isotype
IgG1, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GLE1 RNA export mediator homolog (yeast)
Introduction
This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
2733
UniProt ID
Q53GS7
Alternative Names
GLE1; RNA Export Mediator; GLE1-Like Protein; GLE1L; HGLE1; GLE1 (Yeast Homolog)-Like; RNA Export Mediator; Lethal Congenital Contracture Syndrome 1; GLE1 RNA Export Mediator Homolog (Yeast); GLE1 RNA Export Mediator-Like (Yeast);
Function
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
Biological Process
mRNA export from nucleus Source: GO_Central
Poly(A)+ mRNA export from nucleus Source: InterPro
Protein transport Source: UniProtKB-KW
Regulation of translational initiation Source: GO_Central
Regulation of translational termination Source: GO_Central
Cellular Location
Cytoplasm; Nucleus. Shuttles between the nucleus and the cytoplasm (PubMed:12668658). Shuttling is essential for its mRNA export function (PubMed:12668658).
Isoform 1: Nuclear pore complex; Cytoplasm. Shuttles between the nucleus and the cytoplasm (PubMed:12668658). In the nucleus, isoform 1 localizes to the nuclear pore complex and nuclear envelope (PubMed:12668658). Shuttling is essential for its mRNA export function (PubMed:12668658).
Involvement in disease
Lethal congenital contracture syndrome 1 (LCCS1):
A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS1 patients manifest early fetal hydrops and akinesia, micrognathia, pulmonary hypoplasia, pterygia, and multiple joint contractures. It leads to prenatal death.
Congenital arthrogryposis with anterior horn cell disease (CAAHD):
An autosomal recessive disorder characterized by fetal akinesia, arthrogryposis and motor neuron loss. The fetus often survives delivery, but dies early as a result of respiratory failure. Neuropathological findings resemble those of lethal congenital contracture syndrome type 1, but are less severe.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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