Mouse Anti-GLE1 Recombinant Antibody (1D8) (CBMAB-G3693-LY)

Name: Mouse Anti-GLE1 Recombinant Antibody (1D8)
SKU: CBMAB-G3693-LY
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

1D8

Application

ELISA, IF, WB

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

GLE1 RNA export mediator homolog (yeast)

Introduction

This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

2733

UniProt ID

Q53GS7

Alternative Names

GLE1; RNA Export Mediator; GLE1-Like Protein; GLE1L; HGLE1; GLE1 (Yeast Homolog)-Like; RNA Export Mediator; Lethal Congenital Contracture Syndrome 1; GLE1 RNA Export Mediator Homolog (Yeast); GLE1 RNA Export Mediator-Like (Yeast);

Function

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).

Biological Process

mRNA export from nucleus Source: GO_Central
Poly(A)+ mRNA export from nucleus Source: InterPro
Protein transport Source: UniProtKB-KW
Regulation of translational initiation Source: GO_Central
Regulation of translational termination Source: GO_Central

Cellular Location

Cytoplasm; Nucleus. Shuttles between the nucleus and the cytoplasm (PubMed:12668658). Shuttling is essential for its mRNA export function (PubMed:12668658).
Isoform 1: Nuclear pore complex; Cytoplasm. Shuttles between the nucleus and the cytoplasm (PubMed:12668658). In the nucleus, isoform 1 localizes to the nuclear pore complex and nuclear envelope (PubMed:12668658). Shuttling is essential for its mRNA export function (PubMed:12668658).

Involvement in disease

Lethal congenital contracture syndrome 1 (LCCS1):
A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS1 patients manifest early fetal hydrops and akinesia, micrognathia, pulmonary hypoplasia, pterygia, and multiple joint contractures. It leads to prenatal death.
Congenital arthrogryposis with anterior horn cell disease (CAAHD):
An autosomal recessive disorder characterized by fetal akinesia, arthrogryposis and motor neuron loss. The fetus often survives delivery, but dies early as a result of respiratory failure. Neuropathological findings resemble those of lethal congenital contracture syndrome type 1, but are less severe.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-GLE1 Recombinant Antibody (1D8) (CAT#: V2LY-1225-LY1443)

Related Products

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Mouse Anti-GLE1 Recombinant Antibody (CBLG1-3174) (CAT#: CBMAB-G3694-LY)

Mouse Anti-GLE1 Recombinant Antibody (1D8) (CAT#: V2LY-1225-LY1443)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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