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Rabbit Anti-GLRB Recombinant Antibody (EG1333) (CBMAB-EN1611-LY)

The product is antibody recognizes GLRB. The antibody EG1333 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:40000.
See all GLRB antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1333
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human GLRB.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glycine receptor beta
Introduction
This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human2743
Mouse14658
Rat25456
UniProt ID
HumanP48167
MouseP48168
RatP20781
Alternative Names
HKPX2
Function
Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346).

Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357).

Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346).

Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).
Biological Process
Acrosome reaction Source: Ensembl
Adult walking behavior Source: Ensembl
Chemical synaptic transmission Source: UniProtKB
Chloride transmembrane transport Source: UniProtKB
Gamma-aminobutyric acid receptor clustering Source: Ensembl
Ion transmembrane transport Source: GO_Central
Ion transport Source: UniProtKB
Nervous system development Source: UniProtKB
Nervous system process Source: GO_Central
Neuropeptide signaling pathway Source: UniProtKB
Regulation of membrane potential Source: GO_Central
Response to amino acid Source: GO_Central
Righting reflex Source: Ensembl
Signal transduction Source: GO_Central
Startle response Source: UniProtKB
Synaptic transmission, glycinergic Source: GO_Central
Visual perception Source: Ensembl
Cellular Location
Postsynaptic cell membrane; Cell membrane; Cytoplasm; Synapse; Dendrite. Retained in the cytoplasm upon heterologous expression by itself. Coexpression with GPHN promotes expression at the cell membrane (PubMed:12684523). Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane.
Involvement in disease
Hyperekplexia 2 (HKPX2):
A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli.
Topology
Extracellular: 23-268
Helical: 269-290
Cytoplasmic: 291-295
Helical: 296-316
Extracellular: 317-327
Helical: 328-348
Cytoplasmic: 349-475
Helical: 476-496
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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