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Mouse Anti-GLS2 Recombinant Antibody (585CT26-3-1) (CBMAB-G3897-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
585CT26-3-1
Antibody Isotype
IgM
Application
ELISA, WB

Basic Information

Immunogen
lgA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 150-178 amino acids from the Central region of human lgA
Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glutaminase 2 (liver, mitochondrial)
Introduction
The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Entrez Gene ID
27165
UniProt ID
Q9UI32
Alternative Names
Glutaminase 2; Glutaminase 2 (Liver; Mitochondrial); L-Glutamine Amidohydrolase; EC 3.5.1.2; GLS; GA; Glutaminase Liver Isoform; Mitochondrial; Phosphate-Activated Glutaminase;
Function
Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
Biological Process
Cellular amino acid metabolic process Source: ProtInc
Glutamate biosynthetic process Source: GO_Central
Glutamine catabolic process Source: GO_Central
Reactive oxygen species metabolic process Source: MGI
Regulation of apoptotic process Source: MGI
Cellular Location
Mitochondrion
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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