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Mouse Anti-GLUL Recombinant Antibody (CBT4440) (V2LY-0625-LY1486)


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Tested Data
Mouse Anti-GLUL Recombinant Antibody (CBT4440) (V2LY-0625-LY1486) in ELISA
Mouse Anti-GLUL Recombinant Antibody (CBT4440) (V2LY-0625-LY1486) in ELISA
Mouse Anti-GLUL Recombinant Antibody (CBT4440) (V2LY-0625-LY1486) in WB
Mouse Anti-GLUL Recombinant Antibody (CBT4440) (V2LY-0625-LY1486) in WB
Mouse Anti-GLUL Recombinant Antibody (CBT4440) (V2LY-0625-LY1486) in WB
Mouse Anti-GLUL Recombinant Antibody (CBT4440) (V2LY-0625-LY1486) in WB
Mouse Anti-GLUL Recombinant Antibody (CBT4440) (V2LY-0625-LY1486) in WB
Mouse Anti-GLUL Recombinant Antibody (CBT4440) (V2LY-0625-LY1486) in WB
Mouse Anti-GLUL Recombinant Antibody (CBT4440) (V2LY-0625-LY1486) in FC
Mouse Anti-GLUL Recombinant Antibody (CBT4440) (V2LY-0625-LY1486) in FC
Mouse Anti-GLUL Recombinant Antibody (CBT4440) (V2LY-0625-LY1486) in IHC
Mouse Anti-GLUL Recombinant Antibody (CBT4440) (V2LY-0625-LY1486) in IHC
Mouse Anti-GLUL Recombinant Antibody (CBT4440) (V2LY-0625-LY1486) in IHC
Mouse Anti-GLUL Recombinant Antibody (CBT4440) (V2LY-0625-LY1486) in IHC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4440
Antibody Isotype
IgG1
Application
WB, IHC, FC

Basic Information

Immunogen
Purified recombinant fragment of human GLUL (AA: 2-121) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Glutamate-Ammonia Ligase
Entrez Gene ID
2752
UniProt ID
P15104
Function
Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:30158707, PubMed:16267323).

Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity).

Essential for proliferation of fetal skin fibroblasts (PubMed:18662667).

Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707).

May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707).

Plays a role in ribosomal 40S subunit biogenesis (PubMed:26711351).
Biological Process
Ammonia assimilation cycle Source: Ensembl
Angiogenesis Source: UniProtKB-KW
Cell population proliferation Source: UniProtKB
Cellular response to starvation Source: Ensembl
Glutamate catabolic process Source: BHF-UCL
Glutamine biosynthetic process Source: GO_Central
Positive regulation of epithelial cell proliferation Source: Ensembl
Positive regulation of insulin secretion Source: Ensembl
Positive regulation of synaptic transmission, glutamatergic Source: Ensembl
Protein palmitoylation Source: UniProtKB
Regulation of endothelial cell migration Source: UniProtKB
Regulation of protein localization to nucleolus Source: UniProtKB
Regulation of sprouting angiogenesis Source: UniProtKB
Response to glucose Source: Ensembl
Ribosome biogenesis Source: UniProtKB
Cellular Location
Mitochondrion; Microsome; Cell membrane; Cytosol. Mainly localizes in the cytosol, with a fraction associated with the cell membrane.
Involvement in disease
Congenital systemic glutamine deficiency (CSGD):
Rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid.
PTM
Palmitoylated; undergoes autopalmitoylation.
Ubiquitinated by ZNRF1.
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For research use only. Not intended for any clinical use.

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