Mouse Anti-GNGT2 Recombinant Antibody (1G11-C7) (CBMAB-G4161-LY)

This product is antibody recognizes GNGT2. The antibody 1G11-C7 immunoassay techniques such as: ELISA, WB.
See all GNGT2 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1G11-C7

Antibody Isotype

IgG1, κ

Application

ELISA, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2

Introduction

Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010]

Entrez Gene ID

2793

UniProt ID

O14610

Alternative Names

G Protein Subunit Gamma Transducin 2; Guanine Nucleotide Binding Protein (G Protein); Gamma Transducing Activity Polypeptide 2; Guanine Nucleotide Binding Protein Gamma Transducing Activity Polypeptide 2; G Gamma-C; G-GAMMA-8; G-Gamma-9; GNGT8; GNG9;

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Biological Process

G protein-coupled receptor signaling pathway Source: GO_Central
Phototransduction Source: UniProtKB

Cellular Location

Cell membrane

References

Ibanez, K. R., McFarland, K. N., Phillips, J., Allen, M., Lessard, C. B., Zobel, L., ... & Chakrabarty, P. (2022). Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways. Alzheimer's Research & Therapy, 14(1), 1-27.

Nazlamova, L., Cassidy, E. J., Sowden, J. C., Lotery, A., & Lakowski, J. (2022). Generation of a cone photoreceptor-specific GNGT2 reporter line in human pluripotent stem cells. Stem Cells, 40(2), 190-203.

Liu, G. M., Ji, X., Lu, T. C., Duan, L. W., Jia, W. Y., Liu, Y., ... & Luo, Y. G. (2019). Comprehensive multi-omics analysis identified core molecular processes in esophageal cancer and revealed GNGT2 as a potential prognostic marker. World journal of gastroenterology, 25(48), 6890.

Liu, Y., Wang, L., Yang, B., Su, Y., & Li, Q. (2019). A potential therapeutic target GNGT2 for the EVI1high AML. Genomics and Applied Biology, 38(10), 4763-4768.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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