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Mouse Anti-GOT2 Recombinant Antibody (CBMAB-Z0467-LY)

The product is antibody recognizes GOT2. The antibody immunoassay techniques such as: WB.
See all GOT2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Recombinant protein corresponding to fragment (aa/225-430) GOT2.
Specificity
Human, Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Each vial contains 100 μg IgG in 100 μl of citrate-tris-HCl buffer pH7.0 with 0.02% Proclin300.
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glutamic-oxaloacetic transaminase 2
Entrez Gene ID
Human2806
Mouse14719
UniProt ID
HumanP00505
MouseP05202
Alternative Names
AATM_HUMAN; AL022787; Aspartate aminotransferase; Aspartate aminotransferase 2; Aspartate aminotransferase, mitochondrial; ASPATA; EC 2.6.1.1; FABP 1; FABP pm; FABP-1; FABPpm; Fatty acid binding protein; Fatty acid-binding protein; FLJ40994; Glutamate oxaloacetate transaminase 2; Glutamate oxaloacetate transaminase 2, mitochondrial; Glutamate oxaloacetate transaminase, mitochondrial; Glutamic oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Got 2; GOT2; KAT4; KATIV; Kynurenine aminotransferase IV; mAspAT; MGC102129; MGC115763; mitAAT; mitochondrial; Mitochondrial aspartate aminotransferase; OTTMUSP00000017748; Plasma membrane fatty acid binding protein; Plasma membrane-associated fatty acid-binding protein; Transaminase A.
Function
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.
Biological Process
2-oxoglutarate metabolic process Source: UniProtKB
4-hydroxyproline catabolic process Source: BHF-UCL
Aspartate biosynthetic process Source: Ensembl
Aspartate catabolic process Source: UniProtKB
Aspartate metabolic process Source: UniProtKB
Fatty acid transport Source: UniProtKB
Female pregnancy Source: Ensembl
Glutamate catabolic process to 2-oxoglutarate Source: Ensembl
Glutamate catabolic process to aspartate Source: Ensembl
Glutamate metabolic process Source: UniProtKB
Lactation Source: Ensembl
Oxaloacetate metabolic process Source: Ensembl
Response to ethanol Source: UniProtKB
Response to insulin Source: Ensembl
Response to morphine Source: Ensembl
Response to muscle activity Source: Ensembl
Cellular Location
Mitochondrion matrix; Cell membrane. Exposure to alcohol promotes translocation to the cell membrane.
Involvement in disease
Developmental and epileptic encephalopathy 82 (DEE82):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE82 is an autosomal recessive metabolic encephalopathy characterized by epilepsy from the first year of life, global developmental delay, hypotonia and feeding difficulties apparent soon after birth, and intellectual and motor disabilities. Other features include poor overall growth, progressive microcephaly and biochemical abnormalities, including increased serum lactate and ammonia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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