Mouse Anti-GPAT4 Recombinant Antibody (4C12) (CBMAB-A0183-LY)

Name: Mouse Anti-GPAT4 Recombinant Antibody (4C12)
SKU: CBMAB-A0183-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4C12

Application

WB, ELISA

Immunogen

AGPAT6 (NP_848934.1, 39 a.a. ~ 137 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Glycerol-3-Phosphate Acyltransferase 4

Introduction

Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM

Entrez Gene ID

137964

UniProt ID

Q86UL3

Alternative Names

DKFZp586M1819; LPAAT-zeta; LPAATZ; TSARG7

Function

Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:18238778).

Active against both saturated and unsaturated long-chain fatty acyl-CoAs (PubMed:18238778).

Biological Process

Acyl-CoA metabolic process Source: UniProtKB
CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Diacylglycerol metabolic process Source: Ensembl
Fatty acid metabolic process Source: Ensembl
Glandular epithelial cell maturation Source: Ensembl
Lactation Source: UniProtKB
Lipid biosynthetic process Source: UniProtKB
Phosphatidic acid biosynthetic process Source: Reactome
Phosphatidylcholine biosynthetic process Source: UniProtKB
Regulation of multicellular organism growth Source: Ensembl
Triglyceride biosynthetic process Source: UniProtKB

Cellular Location

Endoplasmic reticulum membrane

Zandieha, S. J., & Khazalia, H. (2022). Effect of intraductal drug delivery of orexin receptor antagonists into rat mammary gland on milk triacylglycerol level: Possible molecular interaction with Gpat1 and Gpat4 genes. Iranian Journal of Pharmaceutical Sciences, 18(2), 87-94.

Shiozaki, Y., Miyazaki–Anzai, S., Okamura, K., Keenan, A. L., Masuda, M., & Miyazaki, M. (2020). GPAT4-generated saturated LPAs induce lipotoxicity through inhibition of autophagy by abnormal formation of omegasomes. Iscience, 23(5), 101105.

Zhu, X. G., Puthenveedu, S. N., Shen, Y., La, K., Ozlu, C., Wang, T., ... & Birsoy, K. (2019). CHP1 regulates compartmentalized glycerolipid synthesis by activating GPAT4. Molecular cell, 74(1), 45-58.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-GPAT4 Recombinant Antibody (4C12) (CAT#: CBMAB-A4434-YC)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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