Rabbit Anti-GPR50 Recombinant Antibody (D1D6I) (CBMAB-G4663-LY)

Name: Rabbit Anti-GPR50 Recombinant Antibody (D1D6I)
SKU: CBMAB-G4663-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

D1D6I

Application

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

G Protein-Coupled Receptor 50

Introduction

This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]

Entrez Gene ID

9248

UniProt ID

Q13585

Alternative Names

G Protein-Coupled Receptor 50; H9; Melatonin-Related Receptor; Mel1c;

Function

Does not bind melatonin.

Biological Process

Cell-cell signaling Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-30
Helical: 31-51
Cytoplasmic: 52-64
Helical: 65-85
Extracellular: 86-103
Helical: 104-124
Cytoplasmic: 125-143
Helical: 144-164
Extracellular: 165-188
Helical: 189-209
Cytoplasmic: 210-239
Helical: 240-260
Extracellular: 261-273
Helical: 274-294
Cytoplasmic: 295-617

Yao, Z., Meng, J., Long, J., Li, L., Qiu, W., Li, C., ... & Ren, P. G. (2023). Orphan receptor GPR50 attenuates inflammation and insulin signaling in 3T3‐L1 preadipocytes. FEBS Open Bio, 13(1), 89-101.

Chen, Y., Zeng, R., Kou, J., Xiong, X., Yao, Y., Fu, W., ... & Lan, D. (2022). GPR50 participates in and promotes yak oocyte maturation: A new potential oocyte regulatory molecule. Theriogenology, 181, 34-41.

Ahmad, R., Lahuna, O., Sidibe, A., Daulat, A., Zhang, Q., Luka, M., ... & Jockers, R. (2020). GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors. Cellular and Molecular Life Sciences, 77, 5189-5205.

Saha, S. K., Choi, H. Y., Yang, G. M., Biswas, P. K., Kim, K., Kang, G. H., ... & Cho, S. G. (2020). GPR50 promotes hepatocellular carcinoma progression via the notch signaling pathway through direct interaction with ADAM17. Molecular Therapy-Oncolytics, 17, 332-349.

Li, Q., Zhang, Y., Ge, B. Y., Li, N., Sun, H. L., Ntim, M., ... & Li, S. (2020). GPR50 distribution in the mouse cortex and hippocampus. Neurochemical Research, 45, 2312-2323.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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