GPR50

This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]

Full Name

G Protein-Coupled Receptor 50

Function

Does not bind melatonin.

Biological Process

Cell-cell signaling Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-30
Helical: 31-51
Cytoplasmic: 52-64
Helical: 65-85
Extracellular: 86-103
Helical: 104-124
Cytoplasmic: 125-143
Helical: 144-164
Extracellular: 165-188
Helical: 189-209
Cytoplasmic: 210-239
Helical: 240-260
Extracellular: 261-273
Helical: 274-294
Cytoplasmic: 295-617

Anti-GPR50 antibodies

Mouse Anti-GPR50 Recombinant Antibody (461129) (CBMAB-G0720-LY)

Datasheet

SDS

Target: GPR50

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 461129

Application*: F

Rabbit Anti-GPR50 Recombinant Antibody (D1D6I) (CBMAB-G4663-LY)

Datasheet

SDS

Target: GPR50

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D1D6I

Application*: WB

Mouse Anti-GPR50 Recombinant Antibody (CBFYH-0460) (CBMAB-H1332-FY)

Datasheet

SDS

Target: GPR50

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYH-0460

Application*: P

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)